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Guidelines

MIRAGE

aldehyde dehydrogenase family 7, member A1

Summary

Gene Symbol

Aldh7a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110695

PubChem

110695

Alliance of Genome Resources

MGI:108186

Annotation

Keyword

Acetylation
Alternative splicing
Cytoplasm
Mitochondrion
NAD
Nucleus
Oxidoreductase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9DBF1	Aldehyde dehydrogenase family 7 member A1 Antiquitin-1 Betaine aldehyde dehydrogenase Delta1-piperideine-6-carboxylate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
glycine betaine biosynthetic process from choline	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

ammonium ion metabolic process [inference]

choline metabolic process [inference]

glycine betaine biosynthetic process from choline

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

choline metabolic process [inference]

glycine betaine biosynthetic process from choline

organonitrogen compound biosynthetic process [inference]

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

choline metabolic process [inference]

glycine betaine biosynthetic process from choline

organonitrogen compound biosynthetic process [inference]

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

glycine betaine metabolic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IEA
mitochondrion	ISO
mitochondrion	HDA	14651853 18614015
cytosol	ISS
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase (NAD+) activity	ISS
aldehyde dehydrogenase (NAD+) activity	ISO
L-aminoadipate-semialdehyde dehydrogenase activity	IEA
betaine-aldehyde dehydrogenase activity	ISS
betaine-aldehyde dehydrogenase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

betaine-aldehyde dehydrogenase activity

L-aminoadipate-semialdehyde dehydrogenase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 5** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080768	pyridoxine-dependent epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

1

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	501	Xenbase:XB-GENE-492001	HUMAN80506
Xenopus tropicalis	110695	Xenbase:XB-GENE-492001
Rattus norvegicus	291450		RATNO13258
Danio rerio	334197		DANRE01232
Canis lupus familiaris	481486		CANLF02054
Monodelphis domestica	100009965		MONDO20425
Equus caballus	100063766		HORSE08977
Ornithorhynchus anatinus	100074256		ORNAN31755
Ciona intestinalis	100184485		CIOIN16027
Salmo salar	100194754		SALSA64526

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025