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solute carrier family 18 (vesicular monoamine), member 1

Summary

Gene Symbol

Slc18a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110877

PubChem

110877

Alliance of Genome Resources

MGI:106684

Annotation

Keyword

Cytoplasmic vesicle
Glycoprotein
Neurotransmitter transport
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8R090	Solute carrier family 18 member 1 Vesicular amine transporter 1
Q32XG7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
aminergic neurotransmitter loading into synaptic vesicle	IBA
positive regulation of dopamine secretion	ISO
xenobiotic transport	IEA
serotonin uptake	ISO
serotonin uptake	IDA	21712771

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

neurotransmitter transport [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

serotonin uptake

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

xenobiotic transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

norepinephrine transport [inference]

norepinephrine uptake

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport [inference]

serotonin transport [inference]

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

norepinephrine transport [inference]

norepinephrine uptake

catecholamine uptake [inference]

organic hydroxy compound transport [inference]

serotonin transport [inference]

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

norepinephrine transport [inference]

norepinephrine uptake

catecholamine uptake [inference]

nitrogen compound transport [inference]

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport [inference]

serotonin transport [inference]

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

norepinephrine transport [inference]

norepinephrine uptake

catecholamine uptake [inference]

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

serotonin uptake

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

neurotransmitter reuptake [inference]

serotonin uptake

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of serotonin uptake [inference]

negative regulation of serotonin uptake

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter uptake [inference]

negative regulation of serotonin uptake

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISO
secretory granule membrane	ISO
synaptic vesicle membrane	IBA
synaptic vesicle membrane	IEA
terminal bouton	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

cell junction [inference]

synapse

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
serotonin:sodium:chloride symporter activity	ISO
serotonin:sodium:chloride symporter activity	IBA
monoamine:proton antiporter activity	ISO
monoamine:proton antiporter activity	IDA	21712771
enzyme binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

antiporter activity [inference]

monoamine:proton antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

xenobiotic transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

serotonin:sodium:chloride symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

binding [inference]

protein binding [inference]

enzyme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vesicular acetylcholine transporter

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
aminergic neurotransmitter loading into synaptic vesicle

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator superfamily

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6570	Xenbase:XB-GENE-940058	HUMAN92804
Xenopus tropicalis	6571	Xenbase:XB-GENE-940058
Drosophila melanogaster	25549	FB:FBgn0260964
Rattus norvegicus	25693	Xenbase:XB-GENE-5738585	RATNO11201
Xenopus tropicalis	110877	Xenbase:XB-GENE-940058
Xenopus tropicalis	180837	Xenbase:XB-GENE-5738585
Drosophila melanogaster	214084	FB:FBgn0260964
Pan troglodytes	464032		PANTR42073
Canis lupus familiaris	486138		CANLF10029
Danio rerio	571483		DANRE43827

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OrthoDB (Group)

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Acknowledgements