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aldo-keto reductase family 1 member C4

Summary

Gene Symbol

AKR1C4

Aliases

3-alpha hydroxysteroid dehydrogenase, type I
3-alpha-HSD
C11
CDR
DD4
HAKRA
MGC22581
chlordecone reductase
dihydrodiol dehydrogenase 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

1109

HGNC

387

KEGG Gene ID

hsa:1109

PubChem

1109

Alliance of Genome Resources

HGNC:387

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Lipid metabolism
NADP
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P17516	3-alpha-hydroxysteroid dehydrogenase type I 3alpha-hydroxysteroid 3-dehydrogenase Chlordecone reductase Dihydrodiol dehydrogenase 4 HAKRA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
steroid metabolic process		8274401
retinoid metabolic process
daunorubicin metabolic process	IBA IMP	20837989
androgen metabolic process		7650035
bile acid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

secondary metabolic process [inference]

polyketide metabolic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

androgen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

androgen metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

androgen metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

olefinic compound metabolic process [inference]

progesterone metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

androgen metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

response to lipid [inference]

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

response to oxygen-containing compound [inference]

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

androgen metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IBA TAS
cytoplasm		2187532
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	20837989
chlordecone reductase activity	IDA	2427522
retinal dehydrogenase activity	IDA	21851338
androsterone dehydrogenase activity	IBA IDA	21851338

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

electron transfer activity

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity

testosterone dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity

testosterone dehydrogenase (NAD+) activity

chlordecone reductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

retinal dehydrogenase activity

transporter activity [inference]

lipid transporter activity [inference]

bile acid transmembrane transporter activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aldo-keto

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
alditol
oxidoreductase activity

Displaying **all 4** entries
InterPro
Aldo-keto reductase
Aldo/keto reductase, conserved site
NADP-dependent oxidoreductase domain superfamily
NADP-dependent oxidoreductase domain

KEGG BRITE Database

Orthology

K00037

Name

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]

References

Rhea

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:34779

a 3α-hydroxysteroid + NAD⁺

H⁺ + a 3-oxosteroid + NADH

Enzyme

PMID

RHEA:20377

androsterone + NADP⁺

H⁺ + 5α-androstan-3,17-dione + NADPH

Enzyme

1.1.1.209

PMID

RHEA:20381

androsterone + NAD⁺

H⁺ + 5α-androstan-3,17-dione + NADH

Enzyme

1.1.1.209

PMID

RHEA:42004

5α-androstane-3α,17β-diol + NAD⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADH

Enzyme

1.1.1.53

PMID

RHEA:34783

a 3α-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

PMID

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:14401

chlordecone alcohol + NADP⁺

H⁺ + chlordecone + NADPH

Enzyme

1.1.1.225

PMID

RHEA:14929

testosterone + NAD⁺

H⁺ + androst-4-ene-3,17-dione + NADH

Enzyme

PMID

RHEA:14981

testosterone + NADP⁺

H⁺ + androst-4-ene-3,17-dione + NADPH

Enzyme

PMID

RHEA:22400

androstan-3α,17β-diol + NAD⁺

H⁺ + NADH + 17β-hydroxyandrostanone

Enzyme

1.1.1.53

PMID

RHEA:16297

5α-androstane-3β,17β-diol + NADP⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADPH

Enzyme

1.1.1.210

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111773	46,XY sex reversal 8	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 5** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000037	Male pseudohermaphroditism
HP:0000062	Ambiguous genitalia
HP:0012245	Sex reversal

Displaying 1 entry
Disease ID	Disease Name
OMIM:614279	46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

PubChem Disease

MedGen Diseases

46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

OMIM Phenotypes

46,XY SEX REVERSAL 8; SRXY8

KEGG Diseases

46,XY gonadal dysgenesis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000718
Gene Name: aldo-keto reductase family 1, member C4

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	27384	MGI:1351662
Drosophila melanogaster	38462	FB:FBgn0035476
Drosophila melanogaster	39305	FB:FBgn0036183
Drosophila melanogaster	39424	FB:FBgn0036290
Mus musculus	77337	MGI:1924587
Mus musculus	83702	MGI:1933427
Mus musculus	105387	MGI:2145458
Mus musculus	116852	MGI:2151104
Caenorhabditis elegans	175047	WB:WBGene00012722
Rattus norvegicus	191574	RGD:708361

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GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements