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Guidelines

MIRAGE

ADAM metallopeptidase with thrombospondin type 1 motif 5

Summary

Gene Symbol

ADAMTS5

Organism

Homo sapiens (human)

External Links

NCBI Gene

11096

PubChem

11096

Alliance of Genome Resources

HGNC:221

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UNA0	A disintegrin and metalloproteinase with thrombospondin motifs 11 ADMP-2 Aggrecanase-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
aortic valve morphogenesis	ISS
pulmonary valve morphogenesis	ISS
endocardial cushion morphogenesis	ISS
proteolysis	IBA
myoblast fusion	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

tissue morphogenesis [inference]

mesenchyme morphogenesis [inference]

endocardial cushion morphogenesis

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IEA
endoplasmic reticulum lumen	TAS
extracellular matrix	IBA
collagen-containing extracellular matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISS
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA	25122765 26668318
metalloendopeptidase activity	IBA
integrin binding	TAS	10438522

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 9** entries
InterPro
ADAM, cysteine-rich domain
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8398	osteoarthritis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Taeniopygia guttata	100227116		TAEGU09969
Callithrix jacchus	100407772		CALJA22102
Pongo abelii	100441162		PONAB21351
Ailuropoda melanoleuca	100469089		AILME11951
Xenopus tropicalis	100488158	Xenbase:XB-GENE-961098
Sus scrofa	100522952		PIGXX05993
Anolis carolinensis	100552915		ANOCA04916
Nomascus leucogenys	100589610		NOMLE23909
Loxodonta africana	100656397		LOXAF14543
Oreochromis niloticus	100694579		ORENI45178

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Last updated: December 8, 2025