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WD repeat domain 6

Summary

Gene Symbol

WDR6

Organism

Homo sapiens (human)

External Links

NCBI Gene

11180

PubChem

11180

Alliance of Genome Resources

HGNC:12758

Annotation

Keyword

Acetylation
Cell cycle
Cytoplasm
Proteomics identification
Reference proteome
Repeat
WD repeat
tRNA processing

Proteins

Displaying **all 6** entries
UniProt	Protein Name
Q9NNW5	WD repeat-containing protein 6
B3KRR8	WD repeat-containing protein 6
Q9H9M3	WD repeat-containing protein 6
E9PDU5	WD repeat-containing protein 6
B4E256	WD repeat-containing protein 6
A0A087X295	WD repeat-containing protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
wobble position ribose methylation	IDA	32558197
negative regulation of cell population proliferation	IDA	17216128
negative regulation of autophagy	IMP	22354037
tRNA methylation	IBA
G1 to G0 transition	IPI	17216128

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

macromolecule methylation [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation

tRNA nucleoside ribose methylation [inference]

wobble position ribose methylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	17216128
cytoplasm	IBA
cytosol	IDA
plasma membrane	IDA
COP9 signalosome	IDA	18850735

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
tRNA binding	IDA	32558197
RNA binding	HDA	22658674
protein binding	IPI	17216128 25416956 32296183
enzyme regulator activity	IDA	32558197

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

tRNA binding

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

WD repeat-containing 6

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
tRNA methylation

Displaying **all 3** entries
InterPro
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	11180	Xenbase:XB-GENE-982770
Mus musculus	83669		MOUSE62637
Rattus norvegicus	301007		RATNO41071
Pan troglodytes	460357		PANTR31097
Bos taurus	526884		BOVIN17863
Canis lupus familiaris	608948		CANLF07523
Macaca mulatta	708505		MACMU29445
Danio rerio	100004270		DANRE42790
Equus caballus	100063394		HORSE12137
Ornithorhynchus anatinus	100073881		ORNAN29383

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OrthoDB (Group)

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Acknowledgements