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Submissions

plakophilin 3

Summary

Gene Symbol

PKP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

11187

PubChem

11187

Alliance of Genome Resources

HGNC:9025

Annotation

Keyword

Alternative promoter usage
Cell adhesion
Cell junction
Cell membrane
Cytoplasm
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y446

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
desmosome assembly	ISS
desmosome assembly	IMP	20859650
regulation of cytokine production involved in immune response	ISS
desmosome organization	ISS
regulation of translation	IMP	25225333

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

epithelial cell-cell adhesion

actin filament-based process [inference]

actin cytoskeleton organization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell-cell junction organization [inference]

desmosome organization

desmosome assembly

cell-cell junction assembly [inference]

desmosome assembly

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of amide metabolic process [inference]

regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of protein metabolic process [inference]

regulation of translation

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of protein metabolic process [inference]

regulation of translation

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cell adhesion

positive regulation of cell-cell adhesion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G1/S phase transition

positive regulation of protein localization

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of hair follicle development

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cell adhesion

positive regulation of cell-cell adhesion

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process

positive regulation of cell adhesion

positive regulation of cell-cell adhesion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G1/S phase transition

positive regulation of protein localization

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G1/S phase transition

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G1/S phase transition

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G1/S phase transition

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response

regulation of hair cycle [inference]

regulation of hair follicle development

regulation of multicellular organismal development [inference]

regulation of hair follicle development

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cornified envelope	TAS
nucleus	IDA	24124604 34058472
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	24124604 25501895 34058472

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cornified envelope

cell junction

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
RNA binding	IEA
protein binding	IPI	24124604 25225333 29678907 32296183 32814053 34058472
enzyme binding	IPI	25225333
alpha-catenin binding	IPI	23136403
cadherin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding

cadherin binding

cadherin binding involved in cell-cell adhesion

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

cadherin binding involved in cell-cell adhesion

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

plakophilin-3

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cadherin binding
cell-cell junction assembly

Displaying **all 4** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Armadillo
Plakophilin/Delta catenin

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	11187	Xenbase:XB-GENE-489317
Mus musculus	56460		MOUSE57018
Rattus norvegicus	293619		RATNO16793
Canis lupus familiaris	483399		CANLF05598
Bos taurus	516247		BOVIN23796
Equus caballus	100147635		HORSE06176
Taeniopygia guttata	100223870		TAEGU25797
Callithrix jacchus	100412402		CALJA03558
Pongo abelii	100457614		PONAB00493
Sus scrofa	100626903		PIGXX16480

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements