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centrosomal protein 250

Summary

Gene Symbol

CEP250

Organism

Homo sapiens (human)

External Links

NCBI Gene

11190

PubChem

11190

Alliance of Genome Resources

HGNC:1859

Annotation

Keyword

3D-structure
Alternative splicing
Cell cycle
Cilium
Cilium biogenesis/degradation
Coiled coil
Cone-rod dystrophy
Cytoskeleton
Deafness
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A9L9PXD2
Q9BV73	250 kDa centrosomal protein Centrosomal Nek2-associated protein 1 Centrosomal protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	IDA	12140259
protein localization	IMP	18851962 23213374
centriole-centriole cohesion	IDA	36282799
centriole-centriole cohesion	IMP	11076968 18851962 23213374 24554434
regulation of centriole-centriole cohesion	IDA	9647649

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

centriole-centriole cohesion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

non-motile cilium assembly

organelle assembly [inference]

cilium assembly

non-motile cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

non-motile cilium assembly

organelle assembly [inference]

cilium assembly

non-motile cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

non-motile cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

non-motile cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

non-motile cilium assembly

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of stimulus involved in sensory perception [inference]

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to centrosome

regulation of protein localization to centrosome [inference]

positive regulation of protein localization to centrosome

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to centrosome

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to centrosome

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centriole-centriole cohesion

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to centrosome

regulation of protein localization to centrosome [inference]

positive regulation of protein localization to centrosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	ISS
photoreceptor inner segment	ISS
centrosome	IDA	21399614 31974111 9647649
centrosome	IBA
centriole	IDA	11076968 18851962 24421332 26337392 27623382 36282799

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

microtubule organizing center

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10880350 18851962 20300119 20708153 30404835 32814053 36217029 9647649
protein domain specific binding	IPI	24554434

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

centrosome-associated protein

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9696	FB:FBgn0039152
Xenopus laevis	11190	Xenbase:XB-GENE-22068258
Mus musculus	16328		MOUSE32430
Danio rerio	42860	ZFIN:ZDB-GENE-081104-380
Rattus norvegicus	311573		RATNO28894
Drosophila melanogaster	381284	FB:FBgn0039152
Pan troglodytes	458203		PANTR24731
Canis lupus familiaris	485851		CANLF09490
Bos taurus	507479		BOVIN05165
Macaca mulatta	705173		MACMU02650