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checkpoint kinase 2

Summary

Gene Symbol

CHEK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

11200

PubChem

11200

Alliance of Genome Resources

HGNC:16627

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Apoptosis
DNA repair
Disease variant
Host-virus interaction
Li-Fraumeni syndrome
Magnesium
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transcription regulation
Tumor suppressor
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O96017	CHK2 checkpoint homolog Cds1 homolog Checkpoint kinase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
DNA damage checkpoint signaling	TAS	10617473 9889122
G2/M transition of mitotic cell cycle	IMP	16481012
double-strand break repair	TAS
double-strand break repair	IMP	18317453
chromatin remodeling	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

protein autophosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

replicative senescence

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

signal transduction in response to DNA damage

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction resulting in transcription [inference]

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

T cell apoptotic process [inference]

thymocyte apoptotic process

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

protein autophosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

replicative senescence

cell division

cellular response to stimulus [inference]

cellular response to stress

cellular response to DNA damage stimulus

DNA repair [inference]

double-strand break repair

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction resulting in transcription [inference]

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to bisphenol A

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to bisphenol A

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

response to stimulus [inference]

response to stress [inference]

cellular response to stress

cellular response to DNA damage stimulus

DNA repair [inference]

double-strand break repair

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction resulting in transcription [inference]

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to gamma radiation [inference]

cellular response to gamma radiation

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to bisphenol A

response to bisphenol A [inference]

cellular response to bisphenol A

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to bisphenol A

response to glycoside

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to bisphenol A

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to bisphenol A

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to bisphenol A

response to glycoside

response to bisphenol A [inference]

cellular response to bisphenol A

cellular response to stimulus [inference]

cellular response to stress

cellular response to DNA damage stimulus

DNA repair [inference]

double-strand break repair

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction resulting in transcription [inference]

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to bisphenol A

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to bisphenol A

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of catabolic process [inference]

regulation of protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator

regulation of cell cycle checkpoint [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator

regulation of cell cycle checkpoint [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

signal transduction in response to DNA damage

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction resulting in transcription [inference]

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator

regulation of cell cycle checkpoint [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

regulation of anoikis [inference]

positive regulation of anoikis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of vacuole organization [inference]

regulation of autophagosome assembly

regulation of organelle assembly [inference]

regulation of autophagosome assembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

positive regulation of cell cycle phase transition [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

mitotic intra-S DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling [inference]

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

negative regulation of cell cycle checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of cellular response to stress [inference]

regulation of DNA damage checkpoint [inference]

negative regulation of DNA damage checkpoint

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	15149599
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

PML body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	TAS	9836640
protein serine/threonine kinase activity	IDA	12717439 16794575 37943659
protein serine/threonine kinase activity	IBA
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine/threonine-protein kinase

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
kinase activity
phosphorylation

Displaying **all 5** entries
InterPro
Forkhead-associated (FHA) domain
Protein kinase domain
Protein kinase-like domain superfamily
SMAD/FHA domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050671	female breast cancer	Alliance of Genome Resources
DOID:0111504	Li-Fraumeni syndrome 2	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1614	male breast cancer	Alliance of Genome Resources
DOID:3347	osteosarcoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 66 in total

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Species	Gene ID	Orthologous MAtrix
Ornithorhynchus anatinus	100077482	ORNAN14217
Sus scrofa	100192447	PIGXX07099
Taeniopygia guttata	100228558	TAEGU06030
Oryctolagus cuniculus	100339430	RABIT14758
Callithrix jacchus	100404949	CALJA18305
Pongo abelii	100461345	PONAB21739
Ailuropoda melanoleuca	100467146	AILME16544
Loxodonta africana	100666208	LOXAF05220
Cavia porcellus	100727440	CAVPO02770
Cricetulus griseus	100769280	CRIGR09096

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements