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CHM Rab escort protein

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1121

PubChem

1121

Alliance of Genome Resources

HGNC:1940

Annotation

Keyword

Alternative splicing
Cytoplasm
Disease variant
GTPase activation
Reference proteome
Transferase
Vision

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P24386	Choroideremia protein Rab escort protein 1 TCD protein
A8K545
B4DRL9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein targeting to membrane	IMP	7957092
intracellular protein transport	IEA
small GTPase mediated signal transduction	IEA
visual perception	IEA
vesicle-mediated transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

macromolecule modification [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

vesicle-mediated transport

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm
cytosol	TAS
cytosol	IMP	7957092
cytosol	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

Rab-protein geranylgeranyltransferase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Rab geranylgeranyltransferase activity	TAS	8380507
GDP-dissociation inhibitor activity	IEA
GTPase activator activity	IEA
protein binding	IPI	21905166 28514442 33961781 35271311
small GTPase binding	IDA	7957092

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

protein prenyltransferase activity [inference]

protein geranylgeranyltransferase activity [inference]

Rab geranylgeranyltransferase activity

catalytic activity, acting on a protein [inference]

protein prenyltransferase activity [inference]

protein geranylgeranyltransferase activity [inference]

Rab geranylgeranyltransferase activity

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rab proteins geranylgeranyltransferase component

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GDP-dissociation inhibitor activity
small GTPase-mediated signal transduction

Displaying **all 2** entries
InterPro
FAD/NAD(P)-binding domain superfamily
GDP dissociation inhibitor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9821	choroideremia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1121	Xenbase:XB-GENE-956389
Xenopus tropicalis	1122	Xenbase:XB-GENE-956389
Mus musculus	12662		MOUSE64984
Rattus norvegicus	24942		RATNO44432
Danio rerio	402935		DANRE21190
Pan troglodytes	465737		PANTR46392
Canis lupus familiaris	480972		CANLF19941
Bos taurus	519552		BOVIN36785
Macaca mulatta	694499		MACMU47186
Equus caballus	100072281		HORSE43919