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MIRAGE

SEC63 homolog, protein translocation regulator

Summary

Gene Symbol

SEC63

Organism

Homo sapiens (human)

External Links

NCBI Gene

11231

PubChem

11231

Alliance of Genome Resources

HGNC:21082

JoGo

SEC63

TogoVar

SEC63

Annotation

Keyword

Chaperone
Coiled coil
Disease variant
Endoplasmic reticulum
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z5M1	DnaJ homolog subfamily C member 23
Q9UGP8	DnaJ homolog subfamily C member 23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
liver development	IEA
protein targeting to membrane	TAS	10799540
SRP-dependent cotranslational protein targeting to membrane	IMP	22375059
SRP-dependent cotranslational protein targeting to membrane	IBA
post-translational protein targeting to endoplasmic reticulum membrane	IMP	22375059

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitrogen cycle metabolic process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
membrane	IDA	22375059
Sec62/Sec63 complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

Sec62/Sec63 complex

endoplasmic reticulum protein-containing complex [inference]

Sec62/Sec63 complex

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
protein binding	IPI	21251912 26871637
protein transmembrane transporter activity	IBA
signaling receptor activity	TAS	10799540

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

macromolecule transmembrane transporter activity [inference]

protein transmembrane transporter activity

protein transporter activity [inference]

protein transmembrane transporter activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNAj

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Chaperone J-domain superfamily
DnaJ domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060975	polycystic liver disease 2	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026