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alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Summary

Gene Symbol

MGAT4B

Aliases

GnT-Ivb

Organism

Homo sapiens (human)

External Links

NCBI Gene

11282

GGDB ID

gg129

HGNC

7048

mRNA

NM_014275

map

5q35

Protein

NP_055090

OMIM

604561

KEGG Gene ID

hsa:11282

PubChem

11282

Alliance of Genome Resources

HGNC:7048

Annotation

Keyword

Alternative splicing
Coiled coil
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UQ53	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein glycosylation	IDA	17006639
protein N-linked glycosylation	IBA
N-glycan processing	TAS	10372966
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

viral process [inference]

viral protein processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
endoplasmic reticulum	IBA
endoplasmic reticulum-Golgi intermediate compartment	IBA
Golgi stack	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053 34981577
acetylglucosaminyltransferase activity	IBA
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	TAS
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA	10372966 17006639
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
acetylglucosaminyltransferase activity
protein N-linked glycosylation

Displaying 1 entry
InterPro
Glycosyl transferase family 54

Human Protein Atlas

ENSG00000161013

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg129

Gene Symbol

MGAT4B

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G10219AA	PA	G20030CU	PA	17006639
UDP-GlcNAc	G39213VZ	PA	G29011JC	PA	17006639

Displaying entries **1 - 5** of 7 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G10219AA	PA	G20030CU	PA	17006639
UDP-GlcNAc	G61751GZ	PA	G92024SL	PA	17006639
UDP-GlcNAc	G80858MF	PA	G61207RZ	PA	17006639
UDP-GlcNAc	G10133VD	PA	G92022ML	PA	17006639
UDP-GlcNAc	G89993FE	PA	G43299SD	PA	17006639

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G12045WP	PA	17006639

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_648721	NM_140464
Mus musculus	NP_666038	NM_145926
Rattus norvegicus	XP_220372	XM_220372

KEGG BRITE Database

Orthology

K00738

Name

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05987	2.4.1.145	G39213VZ	G29011JC

Rhea

RHEA:16057

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.145

PMID

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	11282	ZFIN:ZDB-GENE-040704-19
Drosophila melanogaster	11320	FB:FBgn0036446
Danio rerio	39608	ZFIN:ZDB-GENE-040704-19
Drosophila melanogaster	67555	FB:FBgn0036446
Mus musculus	103534	ZFIN:ZDB-GENE-040704-19	MOUSE04747
Drosophila melanogaster	152586	FB:FBgn0036446
Drosophila melanogaster	269181	FB:FBgn0036446
Rattus norvegicus	303100	ZFIN:ZDB-GENE-040704-19	RATNO02165
Drosophila melanogaster	304646	FB:FBgn0036446
Drosophila melanogaster	367252	FB:FBgn0036446

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements