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Guidelines

MIRAGE

ATP-binding cassette, sub-family A member 4

Summary

Gene Symbol

Abca4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11304

PubChem

11304

Alliance of Genome Resources

MGI:109424

Annotation

Keyword

ATP-binding
Cell projection
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
O35600	ATP-binding cassette sub-family A member 4 RIM ABC transporter Retinal-specific ATP-binding cassette transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process	ISS
phospholipid transfer to membrane	IMP	10412977
lipid transport	IBA
visual perception	IMP	10412977
retinal metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

olefinic compound metabolic process [inference]

retinal metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

photoreceptor cell maintenance

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

organic substance transport [inference]

lipid transport

phospholipid transport [inference]

lipid translocation [inference]

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	IDA	23943788 9202155
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
plasma membrane	TAS	9202155
cytoplasmic vesicle	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

photoreceptor outer segment

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

rod photoreceptor disc membrane

photoreceptor disc membrane [inference]

rod photoreceptor disc membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
GTPase activity	ISS
retinoid binding	ISS
11-cis retinal binding	ISS
11-cis retinal binding	ISO
all-trans retinal binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity

glycerophospholipid flippase activity [inference]

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity

glycerophospholipid flippase activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding

retinal binding [inference]

small molecule binding [inference]

vitamin binding [inference]

retinal binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid transporter activity

flippase activity

glycerophospholipid flippase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family a

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050817	Stargardt disease	Alliance of Genome Resources
DOID:0110354	retinitis pigmentosa 19	Alliance of Genome Resources
DOID:0111013	cone-rod dystrophy 3	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	19	WB:WBGene00000020
Caenorhabditis elegans	20	WB:WBGene00000020
Homo sapiens	24	Xenbase:XB-GENE-1000810	HUMAN50811
Caenorhabditis elegans	10347	WB:WBGene00000020
Caenorhabditis elegans	11303	WB:WBGene00000020
Xenopus tropicalis	11304	Xenbase:XB-GENE-1000810
Caenorhabditis elegans	11305	WB:WBGene00000020
Caenorhabditis elegans	26154	WB:WBGene00000020
Caenorhabditis elegans	27403	WB:WBGene00000020
Caenorhabditis elegans	74591	WB:WBGene00000020

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Last updated: December 8, 2025