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MIRAGE
Parkinsonism associated deglycase
Summary
- Gene Symbol
-
- PARK7
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Autophagy
- Cell membrane
- Chaperone
- Copper
- Cytoplasm
- DNA repair
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Fertilization
- Inflammatory response
- Isopeptide bond
- Mitochondrion
- Neurodegeneration
- Nucleus
- Oxidation
- Palmitate
- Parkinson disease
- Parkinsonism
- Phosphoprotein
- Protease
- RNA-binding
- Reference proteome
- Stress response
- Tumor suppressor
- Ubl conjugation
- Zymogen
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of protein phosphorylation | ||
| positive regulation of acute inflammatory response to antigenic stimulus | ||
| DNA repair | ||
| proteolysis | ||
| autophagy |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of amine metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
negative regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
negative regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
negative regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intracellular signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
negative regulation of signaling [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
negative regulation of apoptotic signaling pathway [inference]
negative regulation of response to stimulus [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intracellular signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intracellular signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of programmed cell death [inference]
regulation of apoptotic process [inference]
negative regulation of apoptotic process [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of neuron apoptotic process
regulation of apoptotic signaling pathway [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of intrinsic apoptotic signaling pathway [inference]
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]
negative regulation of intrinsic apoptotic signaling pathway [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
negative regulation of apoptotic signaling pathway [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of intracellular signal transduction [inference]
negative regulation of apoptotic signaling pathway [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
negative regulation of apoptotic signaling pathway [inference]
regulation of cellular component organization [inference]
regulation of cellular localization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| perinuclear region of cytoplasm | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| core promoter sequence-specific DNA binding | ||
| double-stranded DNA binding | ||
| single-stranded DNA binding | ||
| transcription coactivator activity | ||
| transcription coactivator activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- DJ-1
- Functional Category
-
- K: Transcription
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| glycolate biosynthetic process |
| glyoxal metabolic process |
| oxidoreductase activity, acting on peroxide as acceptor |
| response to oxidative stress |
| InterPro |
|---|
| Class I glutamine amidotransferase-like |
| DJ-1/PfpI |
| Protein/nucleic acid deglycase DJ-1 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060370 | Parkinson's disease 7 | |
| DOID:0080855 | Parkinsonism | |
| DOID:14330 | Parkinson's disease | |
| DOID:3525 | middle cerebral artery infarction | |
| DOID:3526 | cerebral infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 102128495 | MACFA23628 | ||
| 102177646 | CAPHI06848 | ||
| 102441466 | MYOLU14291 | ||
| 102460414 | PELSI04237 | ||
| 103030353 | ASTMX00746 | ||
| 103181420 | CALMI22774 | ||
| 103225666 | CHLSB09430 | ||
| 103260864 | CARSF17329 | ||
| 103666687 | URSMA06301 | ||
| 103820830 | SERCA17618 |
