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cholinergic receptor muscarinic 4

Summary

Gene Symbol

CHRM4

Organism

Homo sapiens (human)

External Links

NCBI Gene

1132

PubChem

1132

Alliance of Genome Resources

HGNC:1953

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P08173

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	TAS	2739737
G protein-coupled acetylcholine receptor signaling pathway	TAS	3443095
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
regulation of locomotion	IEA
G protein-coupled serotonin receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of locomotion

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
postsynaptic membrane	IEA
plasma membrane	IBA TAS
dendrite	IBA
synapse	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 2** entries
GO Term	Evidence Code	PMID
G protein-coupled acetylcholine receptor activity	IBA
G protein-coupled serotonin receptor activity

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

histamine receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12672		MGI:88399	MOUSE33122
Rattus norvegicus	25111		RGD:2344	RATNO29144
Drosophila melanogaster	37892		FB:FBgn0000037
Caenorhabditis elegans	179962		WB:WBGene00001519
Pan troglodytes	466504	9598_0:003297		PANTR02749
Macaca mulatta	574195			MACMU10692
Canis lupus familiaris	611314			CANLF05866
Danio rerio	100004742		ZFIN:ZDB-GENE-090410-7
Ornithorhynchus anatinus	100085485			ORNAN19150
Danio rerio	100150701		ZFIN:ZDB-GENE-090410-6	DANRE40981

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements