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solute carrier family 46 member 1

Summary

Gene Symbol

SLC46A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

113235

PubChem

113235

Alliance of Genome Resources

HGNC:30521

Annotation

Keyword

Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Disease variant
Disulfide bond
Endosome
Folate-binding
Glycoprotein
Phosphoprotein
Reference proteome
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96NT5	Heme carrier protein 1 PCFT/HCP1 Solute carrier family 46 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
intracellular iron ion homeostasis	TAS
folic acid transport	IDA	17129779 17475902 19762432
folic acid transport	IMP	31494288
heme transport	IEA
heme metabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

folic acid metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

pigment metabolic process [inference]

heme metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

folic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

heme metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal folate absorption

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron coordination entity transport [inference]

heme transport

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

intestinal absorption [inference]

intestinal folate absorption

vitamin transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

heme transport

modified amino acid transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

nitrogen compound transport [inference]

heme transport

amide transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

modified amino acid transport [inference]

folic acid transport

intestinal folate absorption

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

import into cell [inference]

folate import across plasma membrane

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GO Term	Evidence Code	PMID
cytoplasm	ISS
endosome	IDA	19074442
plasma membrane	TAS
plasma membrane	IDA	17129779 28112518 29344585 32893190 34619546
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
folic acid binding	IEA
folic acid transmembrane transporter activity	TAS
folic acid transmembrane transporter activity	IDA	17129779 17475902 29344585 32893190 34619546
folic acid transmembrane transporter activity	IMP	19762432
proton transmembrane transporter activity	IDA	17129779

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

folic acid transmembrane transporter activity

folic acid:proton symporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

folic acid transmembrane transporter activity

folic acid:proton symporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

solute:proton symporter activity [inference]

folic acid:proton symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

heme transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

solute:proton symporter activity [inference]

folic acid:proton symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity [inference]

folic acid:proton symporter activity

amide transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folic acid:proton symporter activity

methotrexate transmembrane transporter activity

xenobiotic transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folic acid:proton symporter activity

methotrexate transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folic acid:proton symporter activity

salt transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

binding [inference]

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 46 member

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111678	hereditary folate malabsorption	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	30936	SGD:S000003699
Mus musculus	52466	Xenbase:XB-GENE-961470	MOUSE04760
Saccharomyces cerevisiae S288C	57864	SGD:S000003699
Saccharomyces cerevisiae S288C	71706	SGD:S000003699
Xenopus tropicalis	113235	Xenbase:XB-GENE-961470
Xenopus tropicalis	189356	Xenbase:XB-GENE-961470
Saccharomyces cerevisiae S288C	283537	SGD:S000003699
Saccharomyces cerevisiae S288C	288454	SGD:S000003699
Rattus norvegicus	303333	Xenbase:XB-GENE-961470	RATNO02520
Danio rerio	393255	Xenbase:XB-GENE-961470	DANRE08467

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements