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sphingosine kinase 2

Summary

Gene Symbol

SPHK2

Organism

Pseudonaja textilis

External Links

NCBI Gene: 113443657
KEGG Gene ID: ptex:113443657
PubChem: 113443657

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sphinganine-1-phosphate biosynthetic process	IEA	30032202
sphingosine biosynthetic process	IEA	30032202
positive regulation of apoptotic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	30032202
intracellular membrane-bounded organelle	IEA	30032202
cytoplasm	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying 1 entry
GO Term	Evidence Code	PMID
D-erythro-sphingosine kinase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

D-erythro-sphingosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

D-erythro-sphingosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingosine kinase A

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
D-erythro-sphingosine kinase activity
kinase activity
phosphorylation
sphingosine biosynthetic process

Displaying **all 3** entries
InterPro
Diacylglycerol kinase, catalytic domain
Inorganic polyphosphate/ATP-NAD kinase, N-terminal
NAD kinase/diacylglycerol kinase-like domain superfamily

KEGG BRITE Database

Orthology

K04718

Name

sphingosine kinase [EC:2.7.1.91]

References

Ortholog

Displaying entries **1 - 10** of 38 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	100150090			DANRE11155
Anolis carolinensis	100553460	28377_0:002ce5
Takifugu rubripes	101078125			TAKRU46299
Astyanax mexicanus	103043132			ASTMX09065
Python bivittatus	103057563	176946_0:0008c3
Oreochromis niloticus	106096428			ORENI08090
Thamnophis sirtalis	106538472	35019_0:000ca0
Gekko japonicus	107111139	146911_0:001cec
Gekko japonicus	107125344	146911_0:004b78
Protobothrops mucrosquamatus	107283100	103944_0:000e85

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Last updated: December 9, 2024