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Submissions

acyl-Coenzyme A dehydrogenase, very long chain

Summary

Gene Symbol

Acadvl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11370

PubChem

11370

Alliance of Genome Resources

MGI:895149

Annotation

Keyword

3D-structure
Acetylation
FAD
Fatty acid metabolism
Mitochondrion inner membrane
Oxidoreductase
Phosphoprotein
Reference proteome
S-nitrosylation
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P50544	Long-chain specific acyl-CoA dehydrogenase, mitochondrial MVLCAD

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
temperature homeostasis	IMP	15639194
fatty acid beta-oxidation	ISO
fatty acid catabolic process	IMP	21151927
response to cold	IMP	21151927
epithelial cell differentiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular lipid catabolic process [inference]

fatty acid catabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

response to cold

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

regulation of steroid metabolic process [inference]

regulation of cholesterol metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
nucleolus	ISO
nucleolus	IEA
mitochondrion	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
fatty-acyl-CoA binding	ISO
fatty-acyl-CoA binding	IBA
acyl-CoA dehydrogenase activity	ISS
acyl-CoA dehydrogenase activity	ISO
long-chain-acyl-CoA dehydrogenase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [inference]

acyl-CoA dehydrogenase activity

binding [inference]

protein binding [inference]

identical protein binding

lipid binding [inference]

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

amide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

acyl-CoA binding [inference]

fatty-acyl-CoA binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

flavin adenine dinucleotide binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acyl-CoA dehydrogenase

Functional Category

I: Lipid transport and metabolism
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
flavin adenine dinucleotide binding
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity

Displaying **all 9** entries
InterPro
ACAD9/ACADV-like, C-terminal domain
Acyl-CoA dehydrogenase, conserved site
Acyl-CoA dehydrogenase-like, C-terminal
Acyl-CoA dehydrogenase/oxidase, C-terminal
Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Acyl-CoA dehydrogenase/oxidase, N-terminal
Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Acyl-CoA oxidase/dehydrogenase, middle domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080155	very long chain acyl-CoA dehydrogenase deficiency	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements