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purinergic receptor P2X 5

Summary

Gene Symbol

P2rx5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

113995

PubChem

113995

Alliance of Genome Resources

RGD:620256

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51578	ATP receptor Purinergic receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
monoatomic cation transmembrane transport	IDA ISO	12237343
osteoclast maturation	ISS
regulation of skeletal muscle tissue regeneration	IMP	12135987
response to calcium ion	IDA	12237343
monoatomic cation transport	TAS	12135987

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway

cellular developmental process [inference]

cell maturation [inference]

osteoclast maturation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic anion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

osteoclast maturation

cellular developmental process [inference]

cell maturation [inference]

osteoclast maturation

growth [inference]

developmental growth [inference]

skeletal muscle tissue growth

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to ATP

response to organophosphorus [inference]

response to ATP

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

response to oxygen-containing compound [inference]

response to salt [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic anion transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic anion transmembrane transport

inorganic anion transport [inference]

chloride transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic anion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of skeletal muscle tissue regeneration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of skeletal muscle tissue regeneration

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of skeletal muscle tissue regeneration

regulation of multicellular organismal development [inference]

regulation of skeletal muscle tissue regeneration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of skeletal muscle tissue regeneration

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

Displaying **all 3** entries
GO Term	Evidence Code	PMID
postsynapse	IEA
plasma membrane	IBA ISO ISS
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

postsynapse

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	9855626
voltage-gated monoatomic ion channel activity	IDA	12237343
purinergic nucleotide receptor activity	IEA
ligand-gated monoatomic anion channel activity	ISO ISS
identical protein binding	IDA IPI	15313628 17001079

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

monoatomic anion channel activity [inference]

ligand-gated monoatomic anion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic anion channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

ligand-gated monoatomic anion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

monoatomic anion channel activity [inference]

ligand-gated monoatomic anion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic anion channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic anion channel activity

ATP-gated ion channel activity

extracellularly ATP-gated monoatomic cation channel activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

nucleotide receptor activity [inference]

purinergic nucleotide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

P2X purinoceptor 5

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
calcium ion transmembrane transport
cell surface receptor signaling pathway
cell-cell signaling
excitatory postsynaptic potential
extracellularly ATP-gated monoatomic cation channel activity
monoatomic ion channel activity
monoatomic ion transport
nucleotide binding
regulation of biological quality

Displaying **all 3** entries
InterPro
P2X purinoreceptor extracellular domain superfamily
P2X purinoreceptor
P2X5 purinoceptor

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5026		HGNC:8536	HUMAN30871
Mus musculus	94045	10090_1:0039dc	MGI:2137026	MOUSE07168
Danio rerio	373879		ZFIN:ZDB-GENE-030319-5	DANRE36097
Danio rerio	387299		ZFIN:ZDB-GENE-030319-7
Canis lupus familiaris	448785			CANLF19192
Pan troglodytes	454434			PANTR13260
Macaca mulatta	721476			MACMU15797
Ornithorhynchus anatinus	100077854			ORNAN09096
Taeniopygia guttata	100226199			TAEGU07734
Callithrix jacchus	100411168			CALJA35958

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements