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versican

Summary

Gene Symbol

Vcan

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

114122

PubChem

114122

Alliance of Genome Resources

RGD:619940

Annotation

Keyword

Alternative splicing
Calcium
Cell projection
Disulfide bond
EGF-like domain
Extracellular matrix
Hyaluronic acid
Immunoglobulin domain
Lectin
Phosphoprotein
Proteoglycan
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0G2K944	Chondroitin sulfate proteoglycan core protein 2 Large fibroblast proteoglycan PG-M
A6I4N2	Chondroitin sulfate proteoglycan core protein 2 Large fibroblast proteoglycan PG-M
Q9ERB4	Chondroitin sulfate proteoglycan core protein 2 Glial hyaluronate-binding protein Large fibroblast proteoglycan PG-M
A6I4N1	Chondroitin sulfate proteoglycan core protein 2 Large fibroblast proteoglycan PG-M
D3Z9N6	Chondroitin sulfate proteoglycan core protein 2 Large fibroblast proteoglycan PG-M

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
skeletal system development	IBA
ureteric bud development	ISO
positive regulation of neuroblast proliferation
cell adhesion	IEA
central nervous system development	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell motility [inference]

cell migration [inference]

glial cell migration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development [inference]

axon regeneration

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

animal organ development [inference]

heart development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury [inference]

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	IEA
extracellular region	ISS
extracellular region	ISO
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

interphotoreceptor matrix

perisynaptic extracellular matrix [inference]

perineuronal net

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
hyaluronic acid binding	IEA
protein tyrosine phosphatase activator activity	ISO
protein tyrosine phosphatase activator activity	IEA
protein phosphatase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

low-density lipoprotein particle binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

hyaluronic acid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

protein phosphatase regulator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

versican core protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
central nervous system development
positive regulation of neuroblast proliferation
skeletal system development

Displaying **all 7** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
collagen-containing extracellular matrix	PMID:12586779
cell surface	PMID:12586779
perineuronal net	PMID:16644727

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1462	Xenbase:XB-GENE-922302	HUMAN79922
Mus musculus	13003	Xenbase:XB-GENE-922302	MOUSE11620
Xenopus tropicalis	114122	Xenbase:XB-GENE-922302
Bos taurus	282662		BOVIN33927
Sus scrofa	397328		PIGXX19385
Pan troglodytes	461766		PANTR35167
Canis lupus familiaris	488922		CANLF11899
Macaca mulatta	712365		MACMU38910
Oryctolagus cuniculus	100008666		RABIT01778
Equus caballus	100065275		HORSE08615