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MIRAGE
cholinergic receptor nicotinic epsilon subunit

Summary
Gene Symbol
  • CHRNE
Organism
Homo sapiens (human)
NCBI Gene
1145
PubChem
1145
Alliance of Genome Resources
Annotation
Keyword
  • Cell membrane
  • Congenital myasthenic syndrome
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Ligand-gated ion channel
  • Postsynaptic cell membrane
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q04844
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 10 in total
GO Term Evidence Code PMID
muscle contraction
signal transduction
chemical synaptic transmission
synaptic transmission, cholinergic
monoatomic ion transmembrane transport
GO Hierarchy
Displaying entries 1 - 5 of 6 in total
GO Term Evidence Code PMID
monoatomic cation transmembrane transporter activity
acetylcholine receptor activity
acetylcholine-gated monoatomic cation-selective channel activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
acetylcholine receptor subunit
Functional Category
  • E: Amino acid transport and metabolism
  • T: Signal transduction mechanisms
  • X: Mobilome: prophages, transposons
Displaying all 5 entries
Gene Ontology
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
regulation of postsynaptic membrane potential
Displaying all 8 entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Nicotinic acetylcholine receptor
Disease
Disease Ontology
Displaying all 4 entries
DO ID Disease Name Source
DOID:0110677 congenital myasthenic syndrome 4B
DOID:0110678 congenital myasthenic syndrome 4A
DOID:0110679 congenital myasthenic syndrome 4C
DOID:3635 congenital myasthenic syndrome
Ortholog
Displaying entries 41 - 50 of 93 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
386670 Xenbase:XB-GENE-979686
445315 DANRE35414
446012 TAKRU13567
468165 PANTR13313
479471 CANLF15405
710301 MACMU14436
100017376 MONDO10686
100146223 HORSE03393
100349697 RABIT07252
100391579 CALJA36629
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025