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actin alpha 2, smooth muscle, aorta

Summary

Gene Symbol

Acta2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11475

PubChem

11475

Alliance of Genome Resources

MGI:87909

Annotation

Keyword

ATP-binding
Acetylation
Cytoskeleton
Direct protein sequencing
Hydrolase
Methylation
Muscle protein
Oxidation
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P62737	Alpha-actin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
muscle contraction	ISO
regulation of blood pressure	IMP	11053242
response to virus	IEA
positive regulation of gene expression	ISS
vascular associated smooth muscle contraction	IMP	11053242

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

tissue migration [inference]

mesenchyme migration

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

juxtaglomerular apparatus development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of hepatic stellate cell migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of hepatic stellate cell contraction [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of hepatic stellate cell migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of biological quality [inference]

regulation of blood pressure

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
stress fiber	ISO
stress fiber	IEA
basement membrane	ISO
basement membrane	IEA
cytoplasm	ISO	12355421

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber [inference]

smooth muscle contractile fiber

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber [inference]

smooth muscle contractile fiber

cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

smooth muscle contractile fiber

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23055941
ATP binding	IEA
hydrolase activity	IEA
protein kinase binding	IPI	21307259

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

actin, alpha cardiac muscle 1

Functional Category

K: Transcription
T: Signal transduction mechanisms
Z: Cytoskeleton

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 4** entries
InterPro
ATPase, nucleotide binding domain
Actin family
Actin, conserved site
Actin/actin-like conserved site

Ortholog

Displaying entries **1 - 10** of **273** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	58	SGD:S000001855	HUMAN55121
Homo sapiens	59	Xenbase:XB-GENE-493937	HUMAN02079
Saccharomyces cerevisiae S288C	60	SGD:S000001855
Homo sapiens	70	SGD:S000001855	HUMAN22154
Saccharomyces cerevisiae S288C	71	SGD:S000001855
Homo sapiens	72		HUMAN63291
Saccharomyces cerevisiae S288C	11459	SGD:S000001855
Saccharomyces cerevisiae S288C	11461	SGD:S000001855
Saccharomyces cerevisiae S288C	11464	SGD:S000001855
Saccharomyces cerevisiae S288C	11465	SGD:S000001855

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Acknowledgements