GlyCosmos Portal

Submissions

establishment of sister chromatid cohesion N-acetyltransferase 1

Summary

Gene Symbol

ESCO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

114799

PubChem

114799

Alliance of Genome Resources

HGNC:24645

Annotation

Keyword

3D-structure
Acyltransferase
Alternative splicing
Cell cycle
Chromosome
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5FWF5	CTF7 homolog 1 Establishment factor-like protein 1 Establishment of cohesion 1 homolog 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sister chromatid cohesion	TAS
regulation of DNA replication	IMP	19907496
post-translational protein acetylation	IMP	21111234 27803161
peptidyl-lysine acetylation	IDA	27112597
mitotic sister chromatid cohesion	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine acetylation

protein acylation [inference]

protein acetylation [inference]

post-translational protein modification [inference]

post-translational protein acetylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine acetylation

protein acylation [inference]

protein acetylation [inference]

post-translational protein modification [inference]

post-translational protein acetylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine acetylation

protein acylation [inference]

protein acetylation [inference]

post-translational protein modification [inference]

post-translational protein acetylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine acetylation

protein acylation [inference]

protein acetylation [inference]

post-translational protein modification [inference]

post-translational protein acetylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine acetylation

protein acylation [inference]

protein acetylation [inference]

post-translational protein modification [inference]

post-translational protein acetylation

cellular process [inference]

cell cycle process [inference]

sister chromatid cohesion

mitotic sister chromatid cohesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion

mitotic sister chromatid cohesion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
chromatin	IBA IDA	19907496
nucleus	IBA
chromosome	IDA	15958495

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	IDA	27803161
peptide-lysine-N-acetyltransferase activity	IBA IDA	27112597
acetyltransferase activity	IDA	15958495
N-acetyltransferase activity	IDA TAS	27803161
identical protein binding	IPI	27112597

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity

N-acetyltransferase activity

peptide N-acetyltransferase activity [inference]

peptide-lysine-N-acetyltransferase activity

N-acyltransferase activity [inference]

N-acetyltransferase activity

peptide N-acetyltransferase activity [inference]

peptide-lysine-N-acetyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-lysine-N-acetyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-acetyltransferase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell cycle
metal ion binding
mitotic sister chromatid cohesion
peptide-lysine-N-acetyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
N-acetyltransferase ESCO, acetyl-transferase domain
N-acetyltransferase ESCO, zinc-finger

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5325	Roberts syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 63 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38812		FB:FBgn0035766
Mus musculus	77805		MGI:1925055
Caenorhabditis elegans	176046		WB:WBGene00017269
Pan troglodytes	468494	9598_0:00491f		PANTR15983
Canis lupus familiaris	490523			CANLF17595
Bos taurus	535035			BOVIN19562
Rattus norvegicus	680014		RGD:1596873
Macaca mulatta	698845			MACMU17382
Saccharomyces cerevisiae S288C	850584		SGD:S000001923
Monodelphis domestica	100013062			MONDO19808

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements