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ADAM metallopeptidase domain 19

Summary

Gene Symbol

Adam19

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11492

PubChem

11492

Alliance of Genome Resources

MGI:105377

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3UHT3
Q3UH67
O35674	Meltrin-beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
placenta development	ISS
proteolysis
membrane protein ectodomain proteolysis	IDA	11116142
membrane protein ectodomain proteolysis	IMP	11116142 14975714
membrane protein ectodomain proteolysis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cell-cell adhesion mediated by cadherin [inference]

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
Golgi apparatus	IDA	11116142
external side of plasma membrane	IDA	11116142
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	ISS
metalloendopeptidase activity	ISO
metalloendopeptidase activity	IBA
protein binding	IPI	10527948 10531379 12615925
SH3 domain binding	IMP	12615925

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Disintegrin, conserved site
EGF-like domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Peptidase M12B, propeptide
Reprolysin domain, adamalysin-type

Ortholog

Displaying entries **51 - 60** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101963521	ICTTR11518
Chinchilla lanigera	102016024	CHILA02200
Macaca fascicularis	102143685	MACFA36826
Capra hircus	102178445	CAPHI27084
Myotis lucifugus	102439964	MYOLU05197
Pelodiscus sinensis	102454440	PELSI16114
Astyanax mexicanus	103025209	ASTMX17241
Chlorocebus sabaeus	103244869	CHLSB11158
Ursus maritimus	103664801	URSMA02324
Nannospalax galili	103745467	NANGA23763