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OMA1 zinc metallopeptidase

Summary

Gene Symbol

OMA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

115209

PubChem

115209

Alliance of Genome Resources

HGNC:29661

Annotation

Keyword

Alternative splicing
Autocatalytic cleavage
Disulfide bond
Lipid-binding
Metal-binding
Metalloprotease
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96E52	Metalloprotease-related protein 1 Overlapping with the m-AAA protease 1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	ISS
positive regulation of cold-induced thermogenesis	ISS	22433842
energy homeostasis	ISS
protein autoprocessing	ISS
protein quality control for misfolded or incompletely synthesized proteins	IBA IMP	20038677

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

cellular component assembly [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cristae formation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IDA TAS	32132707
mitochondrial membrane	IDA	20038677
mitochondrial intermembrane space	IDA	32132706 32132707

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA IDA IMP	20038677 25275009 32132706 32132707
lipid binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

lipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entry **81 - 81** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Strigops habroptila	115611574		STRHB12324

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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