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FCH and mu domain containing endocytic adaptor 2

Summary

Gene Symbol

FCHO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

115548

PubChem

115548

Alliance of Genome Resources

HGNC:25180

Annotation

Keyword

3D-structure
Alternative splicing
Coated pit
Coiled coil
Disulfide bond
Endocytosis
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q0JRZ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane invagination	ISS
clathrin coat assembly	IMP	20448150
clathrin coat assembly	IBA
synaptic vesicle endocytosis	IBA
clathrin-dependent endocytosis	IMP	20448150 21762413

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

membrane organization [inference]

membrane invagination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS
plasma membrane	ISS
plasma membrane	IBA
clathrin-coated pit	IDA	21762413 22484487

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

presynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding	ISS
protein binding	IPI	19380743 21762413 22323290 35271311
phosphatidylinositol-4,5-bisphosphate binding	ISS
phosphatidylinositol binding	ISS
identical protein binding	IPI	17540576

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylinositol binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SH3-containing GRB2-like protein 3-interacting protein 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin coat assembly
clathrin-dependent endocytosis

Displaying **all 2** entries
InterPro
Mu homology domain
Muniscin, C-terminal

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	9050	SGD:S000001847
Saccharomyces cerevisiae S288C	9051	SGD:S000001847
Saccharomyces cerevisiae S288C	23149	SGD:S000000626
Saccharomyces cerevisiae S288C	73094	SGD:S000001847
Xenopus tropicalis	115548	Xenbase:XB-GENE-943410
Mus musculus	218503	Xenbase:XB-GENE-943410	MOUSE10362
Rattus norvegicus	309129		RATNO23723
Pan troglodytes	471520		PANTR35333
Canis lupus familiaris	478094		CANLF06770
Danio rerio	553949		DANRE36744