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angiopoietin 2

Summary

Gene Symbol

Angpt2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11601

PubChem

11601

Alliance of Genome Resources

MGI:1202890

Annotation

Keyword

Angiogenesis
Calcium
Coiled coil
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Metal-binding
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B9EHQ4
O35608

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
Tie signaling pathway	IBA ISO TAS	20299672 28179430
negative regulation of cell-substrate adhesion	IDA	9846489
response to organic cyclic compound	IEA
response to glucose	IEA
positive regulation of angiogenesis	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Tie signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell development [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

multicellular organismal process [inference]

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

glomerulus vasculature development

tissue development [inference]

endoderm development

regeneration [inference]

animal organ regeneration

cell development [inference]

animal organ development [inference]

animal organ regeneration

system development [inference]

vasculature development [inference]

renal system vasculature development [inference]

kidney vasculature development [inference]

glomerulus vasculature development

cellular developmental process [inference]

cell development [inference]

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to activity

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organic cyclic compound

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Tie signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of coagulation [inference]

positive regulation of coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	IBA
cell projection	IEA ISO
extracellular space	HDA IBA ISO	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

cell projection

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	28179430 9204896
receptor antagonist activity	TAS	28179430
vascular endothelial growth factor receptor binding	TAS	10051567
metal ion binding	IEA
receptor ligand activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

vascular endothelial growth factor receptor binding

growth factor receptor binding [inference]

vascular endothelial growth factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

Functional Category

I: Lipid transport and metabolism
K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Tie signaling pathway
angiogenesis
cell differentiation
metal ion binding
receptor tyrosine kinase binding

Displaying **all 4** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen, conserved site
Fibrinogen-like, C-terminal

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

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DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources
DOID:0050876	Caroli disease	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:10762	portal hypertension	Alliance of Genome Resources
DOID:10808	gastric ulcer	Alliance of Genome Resources
DOID:13025	retinopathy of prematurity	Alliance of Genome Resources
DOID:1312	focal segmental glomerulosclerosis	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2527	nephrosis	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **119** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5740294	FB:FBgn0087011
Monodelphis domestica	100028850		MONDO03804
Equus caballus	100051890		HORSE25130
Ornithorhynchus anatinus	100073414		ORNAN27748
Taeniopygia guttata	100225992		TAEGU20291
Oryctolagus cuniculus	100353377		RABIT14486
Callithrix jacchus	100404686		CALJA09117
Pongo abelii	100459533		PONAB34459
Ailuropoda melanoleuca	100467094		AILME08543
Anolis carolinensis	100554406		ANOCA01167

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements