GlyCosmos Portal

Submissions

galactosidase, alpha

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11605

PubChem

11605

Alliance of Genome Resources

MGI:1347344

Annotation

Keyword

Disulfide bond
Glycosidase
Lipid metabolism
Lysosome
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UM38
Q8BGZ6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process
lipid metabolic process
oligosaccharide metabolic process	ISS
oligosaccharide metabolic process	ISO
oligosaccharide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

multicellular organismal process [inference]

cell activation [inference]

platelet activation

sleep

developmental process [inference]

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

localization [inference]

maintenance of location [inference]

lipid storage

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of locomotion [inference]

regulation of locomotion involved in locomotory behavior

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of axon diameter

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

regulation of axon diameter

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of locomotion involved in locomotory behavior

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

negative regulation of nitric-oxide synthase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular space	IDA	19710420
cytoplasm	ISS
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
alpha-galactosidase activity	IDA	1008807 10840053 11115376 15629890 198184 205481 2890215 2906327 6251472 6852525 895843
alpha-galactosidase activity	IMP	9122231
alpha-galactosidase activity	IBA
signaling receptor binding	ISS
signaling receptor binding	ISO

GO Hierarchy

molecular function

catalytic activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

galactosidase activity [inference]

alpha-galactosidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate derivative binding [inference]

galactoside binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

galactosidase

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
alpha-galactosidase activity
galactosidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 6** entries
InterPro
Aldolase-type TIM barrel
Alpha galactosidase, C-terminal beta sandwich domain
Glycoside hydrolase family 27/36, conserved site
Glycoside hydrolase superfamily
Glycoside hydrolase, family 27
Glycosyl hydrolase, all-beta

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14499	Fabry disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2717	Xenbase:XB-GENE-1008596	HUMAN101542
Drosophila melanogaster	4668	FB:FBgn0034117
Xenopus tropicalis	11605	Xenbase:XB-GENE-1008596
Drosophila melanogaster	17939	FB:FBgn0034117
Xenopus tropicalis	179660	Xenbase:XB-GENE-1008596
Drosophila melanogaster	315165	FB:FBgn0034117
Rattus norvegicus	363494		RATNO44915
Danio rerio	450083		DANRE07182
Bos taurus	532742		BOVIN36620
Macaca mulatta	703129		MACMU48087

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements