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Guidelines

MIRAGE

tRNA splicing endonuclease subunit 15

Summary

Gene Symbol

TSEN15

Organism

Homo sapiens (human)

External Links

NCBI Gene

116461

PubChem

116461

Alliance of Genome Resources

HGNC:16791

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Endonuclease
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
mRNA processing
tRNA processing

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B1ALV0
E9PPN1
A0A2U3TZM3
Q8WW01	SEN15 homolog tRNA-intron endonuclease Sen15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tRNA splicing, via endonucleolytic cleavage and ligation	IEA
mRNA processing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleolus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleic acid binding	IEA
protein binding	IPI	32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tRNA-splicing endonuclease subunit sen15

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
tRNA processing
tRNA splicing, via endonucleolytic cleavage and ligation

Displaying **all 3** entries
InterPro
tRNA endonuclease-like domain superfamily
tRNA intron endonuclease, catalytic domain-like superfamily
tRNA-splicing endonuclease subunit Sen15

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112329	pontocerebellar hypoplasia type 2F	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

1

2

3

4

5

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	66637		MOUSE27295
Xenopus tropicalis	116461	Xenbase:XB-GENE-983821
Rattus norvegicus	289083		RATNO06713
Pan troglodytes	457576		PANTR23206
Bos taurus	614118		BOVIN08773
Macaca mulatta	717481		MACMU22013
Danio rerio	100005064		DANRE29511
Salmo salar	100195730		SALSA115806
Taeniopygia guttata	100222996		TAEGU29256
Callithrix jacchus	100389141		CALJA16026

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Last updated: December 8, 2025