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potassium two pore domain channel subfamily K member 4

Summary

Gene Symbol

Kcnk4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116489

PubChem

116489

Alliance of Genome Resources

RGD:621449

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Potassium channel
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G3V8V5	TWIK-related arachidonic acid-stimulated potassium channel protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cellular response to mechanical stimulus	ISO ISS
cellular response to arachidonic acid	ISO ISS
detection of mechanical stimulus involved in sensory perception of touch	IMP ISO ISS	31630908
sensory perception of pain	ISO ISS
stabilization of membrane potential

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to pH [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

cellular response to temperature stimulus

response to pH [inference]

response to alkaline pH [inference]

cellular response to alkaline pH

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to pH [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

response to arachidonic acid [inference]

cellular response to arachidonic acid

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to arachidonic acid

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

response to arachidonic acid [inference]

cellular response to arachidonic acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to arachidonic acid

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to arachidonic acid

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to pH [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

stabilization of membrane potential

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA ISO	15677687
node of Ranvier	IDA	31630908
potassium channel complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

node of Ranvier

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mechanosensitived potassium channel activity	IDA ISO	15677687
metal ion binding	IEA
temperature-gated cation channel activity	IDA	15677687
identical protein binding	ISO
potassium channel activity	IDA ISO	11374070 15677687

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

temperature-gated cation channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

temperature-gated cation channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

temperature-gated cation channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

gated channel activity [inference]

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitived potassium channel activity

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

narrow pore channel activity [inference]

leak channel activity [inference]

potassium ion leak channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

potassium channel subfamily K member 4

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 5** entries
Gene Ontology
monoatomic ion transport
outward rectifier potassium channel activity
potassium channel activity
potassium ion leak channel activity
stabilization of membrane potential

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10273	heart conduction disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16528	10090_1:0052eb	MGI:1298234	MOUSE27046
Drosophila melanogaster	32020		FB:FBgn0017561
Homo sapiens	50801		HGNC:6279	HUMAN06872
Caenorhabditis elegans	180054		WB:WBGene00006686
Caenorhabditis elegans	180161		WB:WBGene00006685
Caenorhabditis elegans	190614		WB:WBGene00006695
Caenorhabditis elegans	192070		WB:WBGene00006661
Canis lupus familiaris	612120			CANLF06108
Bos taurus	617184			BOVIN23387
Pan troglodytes	743334			PANTR03285

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Annotation

OrthoDB (Group)

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Acknowledgements