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LDL receptor related protein associated protein 1

Summary

Gene Symbol

Lrpap1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116565

PubChem

116565

Alliance of Genome Resources

RGD:620700

Annotation

Keyword

Coiled coil
Direct protein sequencing
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Lipoprotein
Phosphoprotein
Receptor
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99068	Gp330-binding 45 kDa protein Low density lipoprotein receptor-related protein-associated protein 1
A6IK06

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of receptor internalization	ISO
negative regulation of receptor internalization	IBA
signal transduction	ISO
biological_process	ND
negative regulation of very-low-density lipoprotein particle clearance	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of cellular process [inference]

signal transduction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
endosome	ISS
endosome	ISO
endosome	IBA
endoplasmic reticulum	ISO
endoplasmic reticulum-Golgi intermediate compartment	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10571241
heparin binding	IEA
lipase binding	IBA
lipase binding	IPI	16517593
receptor ligand activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

enzyme binding [inference]

lipase binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin receptor-associated protein

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
heparin binding
lipase binding
low-density lipoprotein particle receptor binding
negative regulation of receptor internalization
negative regulation of very-low-density lipoprotein particle clearance
receptor antagonist activity
very-low-density lipoprotein particle receptor binding

Displaying **all 5** entries
InterPro
Alpha-2-macroglobulin RAP, C-terminal
Alpha-2-macroglobulin RAP, domain 3
Alpha-2-macroglobulin receptor-associated protein, domain 1
Alpha-2-macroglobulin receptor-associated protein
RAP domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
rough endoplasmic reticulum lumen	PMID:8223699
vesicle	PMID:8223699

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4043	Xenbase:XB-GENE-946427	HUMAN74724
Mus musculus	16976	Xenbase:XB-GENE-946427	MOUSE44390
Xenopus tropicalis	116565	Xenbase:XB-GENE-946427
Danio rerio	333939		DANRE49169
Sus scrofa	399654		PIGXX33234
Pan troglodytes	461086		PANTR33213
Canis lupus familiaris	479072		CANLF12162
Macaca mulatta	699677		MACMU35838
Monodelphis domestica	100020963		MONDO28034
Pongo abelii	100172021		PONAB27621