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aldehyde dehydrogenase family 1, subfamily A1

Summary

Gene Symbol

Aldh1a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11668

PubChem

11668

Alliance of Genome Resources

MGI:1353450

Annotation

Keyword

3D-structure
Acetylation
Cell projection
Cytoplasm
Direct protein sequencing
Lipid metabolism
NAD
Oxidoreductase
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P24549	3-deoxyglucosone dehydrogenase ALDH-E1 ALHDII Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase, cytosolic Retinal dehydrogenase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
cellular detoxification of aldehyde	ISO
response to oxidative stress	ISO
fructose catabolic process	IDA	29414685 4343087
response to xenobiotic stimulus	IDA	18971422
9-cis-retinoic acid biosynthetic process	IDA	11876656

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process

hexose catabolic process [inference]

fructose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

lipid metabolic process

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process

hexose catabolic process [inference]

fructose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process

hexose catabolic process [inference]

fructose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

lipid metabolic process

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

olefinic compound metabolic process [inference]

retinol metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

fructosamine metabolic process [inference]

fructosamine catabolic process

amino sugar catabolic process [inference]

fructosamine catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular detoxification [inference]

cellular detoxification of aldehyde

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic eye morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process

9-cis-retinoic acid biosynthetic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	ISO
cytoplasm	IEA
axon	IDA	26430123
synapse	IDA	26430123
cell projection	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
aminobutyraldehyde dehydrogenase activity	IEA IMP	26430123
retinal dehydrogenase activity	ISO
oxidoreductase activity	IEA
3-deoxyglucosone dehydrogenase activity	ISO
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

benzaldehyde dehydrogenase [NAD(P)+] activity [inference]

benzaldehyde dehydrogenase (NAD+) activity

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175691	WB:WBGene00000107
Caenorhabditis elegans	187001	WB:WBGene00000108
Callorhinchus milii	103182367		CALMI24878
Latimeria chalumnae	102347553		LATCH09552
Lepisosteus oculatus	102685231		LEPOC07180
Esox lucius	105014483		ESOLU40235
Salmo trutta	115199852		SALTR20966
Oreochromis niloticus	100710237		ORENI10101
Astatotilapia calliptera	113033456		ASTCA06002
Sparus aurata	115580996		SPAAU14435

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Acknowledgements