GlyCosmos Portal

Submissions

alpha 1 microglobulin/bikunin precursor

Summary

Gene Symbol

Ambp

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11699

PubChem

11699

Alliance of Genome Resources

MGI:88002

Annotation

Keyword

Cell membrane
Chromophore
Cleavage on pair of basic residues
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Extracellular matrix
Mitochondrion inner membrane
Nucleus
Oxidoreductase
Proteoglycan
Reference proteome
Repeat
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07456

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cellular response to reactive oxygen species	ISO ISS
cytochrome c metabolic process	ISO ISS
negative regulation of peptidase activity	IEA
cellular oxidant detoxification	ISO ISS
protein catabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nuclear membrane	IEA
matrix side of mitochondrial inner membrane	ISO
mitochondrial inner membrane	IEA
collagen-containing extracellular matrix	HDA	22159717
plasma membrane	IBA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

nuclear membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

matrix side of mitochondrial inner membrane

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
IgA binding	ISO ISS
oxidoreductase activity	IEA
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISO ISS
antioxidant activity	ISO ISS
serine-type endopeptidase inhibitor activity	IBA IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgA binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

chondroitin sulfate binding

collagen fibril binding

sulfur compound binding [inference]

chondroitin sulfate binding

antioxidant activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Pancreatic trypsin inhibitor Kunitz domain

Functional Category

K: Transcription
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 8** entries
InterPro
Alpha-1-microglobulin
Calycin
Lipocalin family conserved site
Lipocalin/cytosolic fatty-acid binding domain
Pancreatic trypsin inhibitor Kunitz domain superfamily
Pancreatic trypsin inhibitor Kunitz domain
Protein AMBP
Proteinase inhibitor I2, Kunitz, conserved site

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0080652	calcium oxalate nephrolithiasis	Alliance of Genome Resources
DOID:1074	kidney failure	Alliance of Genome Resources
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3021	acute kidney failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **103** in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	259		HGNC:453	HUMAN98130
Rattus norvegicus	25377	10116_1:002184	RGD:2102	RATNO34124
Danio rerio	394093		ZFIN:ZDB-GENE-040426-1608
Xenopus tropicalis	394971		Xenbase:XB-GENE-5747472
Sus scrofa	397593			PIGXX16001
Canis lupus familiaris	481685			CANLF02466
Macaca mulatta	704425			MACMU12223
Pan troglodytes	742026			PANTR44658
Monodelphis domestica	100010064			MONDO06790
Equus caballus	100051766			HORSE24414