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ADCYAP receptor type I

Summary

Gene Symbol

ADCYAP1R1

Organism

Homo sapiens (human)

External Links

NCBI Gene

117

PubChem

117

Alliance of Genome Resources

HGNC:242

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Spermatogenesis
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A994J7E9
P41586
A0A090N8F8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	36385145
spermatogenesis	IEA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

cellular developmental process [inference]

cell differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

development of primary sexual characteristics [inference]

development of primary female sexual characteristics

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

multicellular organismal response to stress

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

development of primary sexual characteristics [inference]

development of primary female sexual characteristics

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to estradiol

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of cellular localization [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to oxidative stress [inference]

negative regulation of response to reactive oxygen species

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to oxidative stress [inference]

negative regulation of response to reactive oxygen species

regulation of response to stress [inference]

regulation of response to oxidative stress [inference]

regulation of response to reactive oxygen species [inference]

negative regulation of response to reactive oxygen species

negative regulation of response to oxidative stress [inference]

negative regulation of response to reactive oxygen species

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transport into cytosol

regulation of cellular localization [inference]

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration [inference]

positive regulation of calcium ion transport into cytosol

regulation of calcium ion transport into cytosol [inference]

positive regulation of calcium ion transport into cytosol

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endosome	IEA
plasma membrane	TAS
plasma membrane	IDA	36385145
plasma membrane	IBA
caveola	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
pituitary adenylate cyclase-activating polypeptide receptor activity	IDA	36385145
vasoactive intestinal polypeptide receptor activity	IEA
protein binding	IPI	17470806 32296183 32814053
adenylate cyclase binding	IEA
G protein-coupled peptide receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

adenylate cyclase binding

GTPase binding [inference]

small GTPase binding

amide binding [inference]

peptide binding [inference]

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vasoactive intestinal polypeptide

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding

Displaying **all 5** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	117	Xenbase:XB-GENE-5805848
Drosophila melanogaster	2692	FB:FBgn0260753
Drosophila melanogaster	2696	FB:FBgn0260753
Drosophila melanogaster	2740	FB:FBgn0260753
Drosophila melanogaster	7433	FB:FBgn0260753
Drosophila melanogaster	7434	FB:FBgn0260753
Mus musculus	11517	Xenbase:XB-GENE-5805848	MOUSE49292
Drosophila melanogaster	14602	FB:FBgn0260753
Drosophila melanogaster	14652	FB:FBgn0260753
Drosophila melanogaster	22354	FB:FBgn0260753

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements