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interleukin 1 receptor type 2

Summary

Gene Symbol

Il1r2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

117022

PubChem

117022

Alliance of Genome Resources

RGD:621147

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P43303	CD121 antigen-like family member B IL-1 type II receptor Interleukin-1 receptor beta Interleukin-1 receptor type II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IBA
negative regulation of protein processing	ISO
negative regulation of protein processing	IEA
protein processing	ISO
protein processing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

Displaying entries **1 - 5** of 6 in total

1

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	ISO
cytoplasm	IEA
plasma membrane	IBA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
interleukin-1 receptor activity	ISO
interleukin-1 receptor activity	IBA
interleukin-1, type II, blocking receptor activity	IEA
interleukin-1 binding	ISO
interleukin-1 binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

interleukin-1 binding

cytokine binding [inference]

interleukin-1 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-1 receptor type 2

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
cytokine-mediated signaling pathway
inflammatory response
interleukin-1 binding
interleukin-1 receptor activity

Displaying **all 7** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-1 receptor family
Interleukin-1 receptor type I/II
Interleukin-1 receptor type II

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements