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peroxiredoxin 3

Summary

Gene Symbol

Prdx3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11757

PubChem

11757

Alliance of Genome Resources

MGI:88034

Annotation

Keyword

Acetylation
Antioxidant
Cytoplasm
Direct protein sequencing
Disulfide bond
Endosome
Mitochondrion
Palmitate
Peroxidase
Phosphoprotein
Redox-active center
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P20108	Antioxidant protein 1 PRX III Perioredoxin-3 Protein MER5 Thioredoxin-dependent peroxiredoxin 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA ISO
cellular response to reactive oxygen species	IEA ISO
cell redox homeostasis	IBA
maternal placenta development	IMP	18544346
peptidyl-cysteine oxidation	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

macromolecule modification [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy [inference]

maternal placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

anatomical structure development [inference]

maternal placenta development

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to reactive oxygen species [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
early endosome	IEA ISO
protein-containing complex	IEA ISO
intracellular membrane-bounded organelle	ISO
plasma membrane	IEA ISO
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
thioredoxin peroxidase activity	IBA IEA ISO
identical protein binding	IPI ISO	11591653
protein kinase binding	IEA ISO
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

antioxidant activity [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

thioredoxin-dependent peroxide reductase, mitochondrial

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 7** entries
Gene Ontology
antioxidant activity
cellular oxidant detoxification
cellular response to stress
hydrogen peroxide catabolic process
oxidoreductase activity
peroxiredoxin activity
response to oxidative stress

Displaying **all 4** entries
InterPro
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Peroxiredoxin, C-terminal
Thioredoxin domain
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070413	autosomal recessive spinocerebellar ataxia 32	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10935		HGNC:9354	HUMAN03140
Drosophila melanogaster	42109		FB:FBgn0038519
Rattus norvegicus	64371	10116_1:0000cc	RGD:620040	RATNO20779
Caenorhabditis elegans	175573		WB:WBGene00011110
Bos taurus	281998			BOVIN21646
Danio rerio	373079		ZFIN:ZDB-GENE-030826-18
Canis lupus familiaris	477839			CANLF11523
Xenopus tropicalis	594996		Xenbase:XB-GENE-994377
Macaca mulatta	702882			MACMU45126
Pan troglodytes	741184			PANTR01660

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements