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peroxiredoxin 3

Summary

Gene Symbol

Prdx3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11757

PubChem

11757

Alliance of Genome Resources

MGI:88034

Annotation

Keyword

Acetylation
Antioxidant
Cytoplasm
Direct protein sequencing
Disulfide bond
Endosome
Mitochondrion
Palmitate
Peroxidase
Phosphoprotein
Redox-active center
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P20108	Antioxidant protein 1 PRX III Perioredoxin-3 Protein MER5 Thioredoxin-dependent peroxiredoxin 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA ISO
cellular response to reactive oxygen species	IEA ISO
cell redox homeostasis	IBA
maternal placenta development	IMP	18544346
peptidyl-cysteine oxidation	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

macromolecule modification [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein oxidation [inference]

peptidyl-cysteine oxidation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine oxidation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy [inference]

maternal placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

anatomical structure development [inference]

maternal placenta development

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to reactive oxygen species [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA IBA ISO	14651853 18614015
myelin sheath	HDA	17634366
cytosol	IBA IEA ISO
cytoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
thioredoxin peroxidase activity	IBA IEA ISO
identical protein binding	IPI ISO	11591653
protein kinase binding	IEA ISO
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

antioxidant activity [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

thioredoxin-dependent peroxide reductase, mitochondrial

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 7** entries
Gene Ontology
antioxidant activity
cellular oxidant detoxification
cellular response to stress
hydrogen peroxide catabolic process
oxidoreductase activity
peroxiredoxin activity
response to oxidative stress

Displaying **all 4** entries
InterPro
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Peroxiredoxin, C-terminal
Thioredoxin domain
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070413	autosomal recessive spinocerebellar ataxia 32	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **115** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	852064	SGD:S000002861
Saccharomyces cerevisiae S288C	854980	SGD:S000004490
Monodelphis domestica	100020372		MONDO03267
Ornithorhynchus anatinus	100088874		ORNAN07509
Sus scrofa	100154143		PIGXX08588
Pongo abelii	100174238		PONAB01644
Ciona intestinalis	100175802		CIOIN13535
Taeniopygia guttata	100226317		TAEGU26595
Callithrix jacchus	100399960		CALJA06268
Ailuropoda melanoleuca	100478555		AILME16686

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OrthoDB (Group)

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Acknowledgements