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adaptor-related protein complex 2, alpha 2 subunit

Summary

Gene Symbol

Ap2a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11772

PubChem

11772

Alliance of Genome Resources

MGI:101920

Annotation

Keyword

3D-structure
Cell membrane
Coated pit
Endocytosis
Lipid-binding
Protein transport
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6PEE6
P17427	100 kDa coated vesicle protein C Adaptor protein complex AP-2 subunit alpha-2 Adaptor-related protein complex 2 subunit alpha-2 Alpha-adaptin C Alpha2-adaptin Clathrin assembly protein complex 2 alpha-C large chain Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Q69ZW4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	TAS	9714600
vesicle-mediated transport	NAS	15941406
vesicle-mediated transport	TAS	9714600
synaptic vesicle endocytosis	NAS	35014951
synaptic vesicle endocytosis	IDA	35014951

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
synaptic vesicle	ISO
cytoplasmic side of plasma membrane	NAS	29184887
membrane coat	IDA	11879655
AP-2 adaptor complex	ISO
AP-2 adaptor complex	NAS	12086608

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat

AP-type membrane coat adaptor complex [inference]

clathrin adaptor complex [inference]

AP-2 adaptor complex

plasma membrane protein complex [inference]

AP-2 adaptor complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11470803 17182770 23676497
lipid binding	IEA
kinase binding	IPI	17880279
protein kinase binding	IPI	21307259
protein domain specific binding	IPI	12732633

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

protein kinase binding

protein serine/threonine kinase binding

protein domain specific binding

disordered domain specific binding

lipid binding

phospholipid binding [inference]

phosphatidylinositol binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

AP-2 complex subunit alpha-2

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin adaptor activity
clathrin-dependent endocytosis

Displaying **all 9** entries
InterPro
Adaptor protein complex AP-2, alpha subunit
Armadillo-like helical
Armadillo-type fold
Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
Clathrin adaptor, appendage, Ig-like subdomain superfamily
Clathrin/coatomer adaptor, adaptin-like, N-terminal
Coatomer/calthrin adaptor appendage, C-terminal subdomain
TBP domain superfamily

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	160	SGD:S000000133
Homo sapiens	161	Xenbase:XB-GENE-486024	HUMAN03788
Saccharomyces cerevisiae S288C	11771	SGD:S000000133
Xenopus tropicalis	11772	Xenbase:XB-GENE-486024
Rattus norvegicus	81637		RATNO20744
Canis lupus familiaris	475994		CANLF05896
Bos taurus	515216		BOVIN23744
Macaca mulatta	720875		MACMU09328
Xenopus tropicalis	852243	Xenbase:XB-GENE-486024
Equus caballus	100056318		HORSE06080