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adaptor-related protein complex 2, mu 1 subunit

Summary

Gene Symbol

Ap2m1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11773

PubChem

11773

Alliance of Genome Resources

MGI:1298405

Annotation

Keyword

3D-structure
Cell membrane
Coated pit
Direct protein sequencing
Endocytosis
Lipid-binding
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q5FWI9	AP-2 mu chain Clathrin assembly protein complex 2 mu medium chain Clathrin coat assembly protein AP50 Clathrin coat-associated protein AP50 Plasma membrane adaptor AP-2 50 kDa protein
Q3TWV4
P84091	AP-2 mu chain Adaptor protein complex AP-2 subunit mu Adaptor-related protein complex 2 subunit mu Clathrin assembly protein complex 2 mu medium chain Clathrin coat assembly protein AP50 Clathrin coat-associated protein AP50 Mu2-adaptin Plasma membrane adaptor AP-2 50 kDa protein
Q6A0C9	AP-2 mu chain Clathrin assembly protein complex 2 mu medium chain Clathrin coat assembly protein AP50 Clathrin coat-associated protein AP50 Plasma membrane adaptor AP-2 50 kDa protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
positive regulation of receptor internalization	ISO
positive regulation of receptor internalization	IEA
intracellular protein transport	TAS	9714600
vesicle budding from membrane	ISO
vesicle budding from membrane	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle budding from membrane

cellular component assembly [inference]

protein-containing complex assembly

regulation of cellular component size [inference]

regulation of vesicle size

protein-containing complex organization [inference]

protein-containing complex assembly

membrane organization [inference]

vesicle budding from membrane

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of synaptic vesicle endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of vesicle size

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA	14651853
plasma membrane	ISO
clathrin-coated pit	ISO
synaptic vesicle	IEA
cytoplasmic side of plasma membrane	NAS	29184887

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

AP-type membrane coat adaptor complex [inference]

clathrin adaptor complex [inference]

AP-2 adaptor complex

plasma membrane protein complex [inference]

AP-2 adaptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of presynaptic membrane [inference]

extrinsic component of presynaptic endocytic zone membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
signal sequence binding	ISO
signal sequence binding	IEA
protein binding	IPI	18321067 23676497
lipid binding	IEA
clathrin adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

protein domain specific binding [inference]

disordered domain specific binding

transmembrane transporter binding

lipid binding

amide binding [inference]

peptide binding [inference]

signal sequence binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complex, subunit

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
clathrin adaptor activity

Displaying **all 6** entries
InterPro
AP complex, mu/sigma subunit
AP-2 complex subunit mu, C-terminal superfamily
Clathrin adaptor, mu subunit, conserved site
Clathrin adaptor, mu subunit
Longin-like domain superfamily
Mu homology domain

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1173	Xenbase:XB-GENE-6258427	HUMAN73717
Xenopus tropicalis	11773	Xenbase:XB-GENE-6258427
Rattus norvegicus	116563		RATNO03843
Danio rerio	394001		DANRE13669
Bos taurus	517446		BOVIN14890
Canis lupus familiaris	607139		CANLF13523
Macaca mulatta	703554		MACMU28712
Pan troglodytes	736431		PANTR32789
Monodelphis domestica	100011981		MONDO13944
Pongo abelii	100174724		PONAB25103

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements