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Charcot-Leyden crystal galectin

Summary

Gene Symbol

Aliases

Gal-10
LGALS10
MGC149659
eosinophil lysophospholipase
galectin 10
lectin, galactoside-binding, soluble, 10
lysolecithin acylhydrolase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1178

HGNC

2014

KEGG Gene ID

hsa:1178

PubChem

1178

Alliance of Genome Resources

HGNC:2014

JoGo

CLC

TogoVar

CLC

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Lectin
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q05315	Charcot-Leyden crystal protein Eosinophil lysophospholipase Lysolecithin acylhydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of T cell anergy	IMP	17502455
regulation of T cell cytokine production	IMP	17502455
regulation of activated T cell proliferation	IMP	17502455
T cell apoptotic process	IDA	17502455

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

T cell apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

regulation of T cell tolerance induction [inference]

regulation of T cell anergy

regulation of lymphocyte anergy [inference]

regulation of T cell anergy

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of leukocyte mediated immunity [inference]

regulation of lymphocyte mediated immunity [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of immune response [inference]

regulation of adaptive immune response [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of response to stimulus [inference]

regulation of immune response [inference]

regulation of adaptive immune response [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of cell population proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

regulation of activated T cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IDA	17502455
collagen-containing extracellular matrix	HDA	28344315

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lysophospholipase activity	IDA	11834744
protein binding	IPI	11834744
carbohydrate binding	IBA
identical protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

lysophospholipase activity

carboxylic ester hydrolase activity [inference]

lysophospholipase activity

binding [inference]

protein binding

identical protein binding

carbohydrate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

galectin

Functional Category

K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Galectin, carbohydrate recognition domain
Galectin-like

KEGG BRITE Database

Orthology

K13334

Name

eosinophil lysophospholipase (galectin-10) [EC:3.1.1.5]

References

8419478

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025

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Acknowledgements