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amyloid beta precursor-like protein 2

Summary

Gene Symbol

Aplp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11804

PubChem

11804

Alliance of Genome Resources

MGI:88047

Annotation

Keyword

Alternative splicing
Cell membrane
Copper
DNA-binding
Disulfide bond
Glycoprotein
Metal-binding
Nucleus
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q64348
Q60709	Amyloid beta (A4) precursor-like protein 2 Amyloid protein homolog Amyloid-like protein 2 CDEI box-binding protein Sperm membrane protein YWK-II
Q06335	Amyloid beta (A4) precursor-like protein 2 Amyloid protein homolog Amyloid-like protein 2 CDEI box-binding protein Sperm membrane protein YWK-II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
suckling behavior	IGI	9461064
intracellular copper ion homeostasis	IMP	10526140
regulation of epidermal growth factor-activated receptor activity	IGI	17556541
axonogenesis	IBA
central nervous system development	IBA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

reproductive behavior [inference]

mating behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organism development [inference]

embryo development

behavior [inference]

locomotory behavior

feeding behavior [inference]

suckling behavior

reproductive behavior [inference]

mating behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development

system development [inference]

central nervous system development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

inorganic ion homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity

regulation of binding [inference]

regulation of protein binding

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IEA
plasma membrane	IEA
endomembrane system
membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

spine apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
serine-type endopeptidase inhibitor activity	ISO
protein binding	IPI	16193067 16314516 17934213 8894693
heparin binding	IEA
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amyloid beta precursor protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
central nervous system development
heparin binding
metal ion binding
serine-type endopeptidase inhibitor activity
transition metal ion binding

Displaying entries **1 - 10** of 15 in total

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InterPro
Amyloidogenic glycoprotein, E2 domain
Amyloidogenic glycoprotein, copper-binding domain conserved site
Amyloidogenic glycoprotein, copper-binding domain superfamily
Amyloidogenic glycoprotein, copper-binding
Amyloidogenic glycoprotein, extracellular
Amyloidogenic glycoprotein, heparin-binding domain superfamily
Amyloidogenic glycoprotein, heparin-binding
Amyloidogenic glycoprotein, intracellular domain, conserved site
Amyloidogenic glycoprotein
Beta-amyloid precursor protein C-terminal