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MIRAGE
chloride voltage-gated channel 2
Summary
- Gene Symbol
-
- CLCN2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- CBS domain
- Cell membrane
- Cell projection
- Chloride channel
- Disease variant
- Epilepsy
- Phosphoprotein
- Postsynaptic cell membrane
- Reference proteome
- Repeat
- Transmembrane helix
- Voltage-gated channel
- Proteins
| UniProt | Protein Name |
|---|---|
| P51788 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| acinar cell differentiation | ||
| regulation of membrane depolarization during action potential | ||
| chloride transmembrane transport |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| basolateral plasma membrane | ||
| dendritic spine membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| voltage-gated chloride channel activity | ||
| voltage-gated chloride channel activity | ||
| protein binding | ||
| chloride channel regulator activity | ||
| volume-sensitive chloride channel activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Chloride channel
- Functional Category
-
- E: Amino acid transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| chloride transmembrane transport |
| chloride transport |
| monoatomic ion transport |
| voltage-gated chloride channel activity |
| InterPro |
|---|
| CBS domain superfamily |
| Chloride channel, core |
| Chloride channel, voltage gated |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111312 | obsolete idiopathic generalized epilepsy 11 | |
| DOID:446 | primary hyperaldosteronism |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 488106 | CANLF13535 | ||
| 505569 | BOVIN14870 | ||
| 704709 | MACMU28824 | ||
| 100009530 | RABIT04644 | ||
| 100092252 | ORNAN12575 | ||
| 100135500 | CAVPO04541 | ||
| 100333644 | DANRE51676 | ||
| 100393718 | CALJA13209 | ||
| 100450932 | PONAB25186 | ||
| 100465567 | AILME16410 |
