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MIRAGE

ATPase, H+ transporting, lysosomal V0 subunit A1

Summary

Gene Symbol

Atp6v0a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11975

PubChem

11975

Alliance of Genome Resources

MGI:103286

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasmic vesicle
Direct protein sequencing
Hydrogen ion transport
Phosphoprotein
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9Z1G4	Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit Vacuolar adenosine triphosphatase subunit Ac116 Vacuolar proton pump subunit 1 Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Q99M55
Q3TY98
Q3TXT5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
vacuolar acidification	IBA
regulation of macroautophagy	ISO
regulation of macroautophagy	IEA
synaptic vesicle lumen acidification	EXP	28793259
synaptic vesicle lumen acidification	IDA	28793259

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

neuron cellular homeostasis [inference]

synaptic vesicle lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

establishment of localization in cell [inference]

synaptic vesicle lumen acidification

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

Displaying entries **1 - 5** of 21 in total

1

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GO Term	Evidence Code	PMID
vacuolar proton-transporting V-type ATPase, V0 domain	ISS
cytoplasm	IDA	10722719
Golgi apparatus	ISO
Golgi apparatus	IEA
cytosol	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex [inference]

vacuolar proton-transporting V-type ATPase complex

proton-transporting two-sector ATPase complex, proton-transporting domain [inference]

proton-transporting V-type ATPase, V0 domain [inference]

vacuolar proton-transporting V-type ATPase, V0 domain

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex [inference]

vacuolar proton-transporting V-type ATPase complex

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20541250
proton-transporting ATPase activity, rotational mechanism	IEA
ATPase binding	ISO
ATPase binding	IBA
ATPase binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

binding [inference]

protein binding

enzyme binding [inference]

ATPase binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

C: Energy production and conversion
D: Cell cycle control, cell division, chromosome partitioning
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATPase binding
monoatomic ion transport
proton-transporting ATPase activity, rotational mechanism
vacuolar acidification

Displaying **all 2** entries
InterPro
ATPase, V0 complex, subunit 116kDa, eukaryotic
V-type ATPase, V0 complex, 116kDa subunit family

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026