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ATPase phospholipid transporting 8A1

Summary

Gene Symbol

Atp8a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11980

PubChem

11980

Alliance of Genome Resources

MGI:1330848

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cytoplasmic vesicle
Endoplasmic reticulum
Golgi apparatus
Lipid transport
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q52KQ7
A0A0M3HEP7
Q8CA15
Q3U9N5
P70704	ATPase class I type 8A member 1 Chromaffin granule ATPase II P4-ATPase flippase complex alpha subunit ATP8A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
learning	IMP	22007859
positive regulation of cell migration	IMP	23269685
phospholipid translocation	IBA
synaptic vesicle endocytosis	EXP	37723322
synaptic vesicle endocytosis	IEP	37723322

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

nitrogen compound transport [inference]

aminophospholipid transport [inference]

aminophospholipid translocation

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA
Golgi apparatus	ISO
Golgi apparatus	IEA
trans-Golgi network	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
protein binding	IPI	23269685 30086173
ATP binding	IEA
ATP hydrolysis activity	IEA
phosphatidylserine floppase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

phosphatidylserine floppase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

floppase activity [inference]

phosphatidylserine floppase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

aminophospholipid flippase activity [inference]

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylserine flippase activity

floppase activity [inference]

phosphatidylserine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
lipid translocation
magnesium ion binding
metal ion binding
nucleotide binding
phospholipid translocation
phospholipid transport

Displaying entries **1 - 10** of 11 in total

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InterPro
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, C-terminal
P-type ATPase, N-terminal
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, subfamily IV
P-type ATPase, transmembrane domain superfamily