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solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

Summary

Gene Symbol

Slc7a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11988

PubChem

11988

Alliance of Genome Resources

MGI:99828

Annotation

Keyword

Alternative splicing
Amino-acid transport
Cell membrane
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18581	20.5 Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2 T-cell early activation protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
L-arginine transmembrane transport	IDA IMP ISO	11278602 12675924 9174363
regulation of macrophage activation	IMP	16670299
establishment of localization in cell	IMP	11278602 12675924
L-amino acid transport	ISO
macrophage activation	IMP	16703566

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

production of molecular mediator involved in inflammatory response [inference]

nitric oxide production involved in inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

modified amino acid transport [inference]

import into cell [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cell junction	ISO
membrane	IDA	8187816
plasma membrane	IBA IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
L-arginine transmembrane transporter activity	IBA IDA IMP ISO	11278602 12675924 9174363
L-lysine transmembrane transporter activity	IBA
amino acid transmembrane transporter activity	ISO
L-amino acid transmembrane transporter activity	ISO
L-ornithine transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-lysine transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cationic amino acid transporter 2

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
L-ornithine transmembrane transporter activity

Displaying **all 2** entries
InterPro
Amino acid/polyamine transporter I
Cationic amino acid transporter, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111666	proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **118** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6542		HGNC:11060	HUMAN92671
Drosophila melanogaster	39662		FB:FBgn0036493
Drosophila melanogaster	39990		FB:FBgn0036764
Drosophila melanogaster	40510		FB:FBgn0037203
Rattus norvegicus	64554	10116_1:004a79	RGD:68387	RATNO10931
Canis lupus familiaris	475614			CANLF04753
Danio rerio	494041		ZFIN:ZDB-GENE-041212-5
Bos taurus	538708			BOVIN22002
Macaca mulatta	710629			MACMU43542
Pan troglodytes	740548			PANTR42032