leucine rich repeat kinase 2
| GO Term | Evidence Code | PMID |
|---|---|---|
| striatum development | ||
| olfactory bulb development | ||
| tangential migration from the subventricular zone to the olfactory bulb | ||
| regulation of cell projection organization | ||
| positive regulation of protein ubiquitination |
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| extracellular space | ||
| nucleoplasm | ||
| cytoplasm | ||
| cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone H2BS36 kinase activity | ||
| histone H3S57 kinase activity | ||
| histone H3T45 kinase activity | ||
| beta-catenin destruction complex binding | ||
| histone H2AT120 kinase activity |
| Gene Ontology |
|---|
| ATP binding |
| GTP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060371 | Parkinson's disease 8 | |
| DOID:0080855 | Parkinsonism | |
| DOID:14330 | Parkinson's disease | |
| DOID:162 | cancer | |
| DOID:8778 | Crohn's disease |
| HPO ID | HPO Term |
|---|---|
| HP:0003677 | Slowly progressive |
| HP:0003829 | Typified by incomplete penetrance |
| HP:0004409 | Hyposmia |
| HP:0004926 | Orthostatic hypotension due to autonomic dysfunction |
| HP:0005340 | Spastic/hyperactive bladder |
| HP:0011960 | Substantia nigra gliosis |
| HP:0012332 | Abnormal autonomic nervous system physiology |
| HP:0012450 | Chronic constipation |
| HP:0012452 | Restless legs |
| HP:0012760 | Reduced social reciprocity |
| Disease ID | Disease Name |
|---|---|
| ORPHA:411602 |
|
| ORPHA:2828 |
|
| OMIM:607060 |
|
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 66725 | MOUSE17281 | ||
| 120892 | Xenbase:XB-GENE-5768572 | ||
| 300160 | RATNO37847 | ||
| 486608 | CANLF10919 | ||
| 535652 | BOVIN29401 | ||
| 559366 | DANRE27769 | ||
| 697930 | MACMU04394 | ||
| 745893 | PANTR06140 | ||
| 780403 | PIGXX26493 | ||
| 100019429 | MONDO33161 |
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
This work is licensed under Creative Commons Attribution 4.0 International
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Last updated: December 8, 2025