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H4 histone 16

Summary

Gene Symbol

H4C16

Organism

Homo sapiens (human)

External Links

NCBI Gene

121504

PubChem

121504

Alliance of Genome Resources

HGNC:20510

Annotation

Keyword

3D-structure
Acetylation
Chromosomal rearrangement
Citrullination
Direct protein sequencing
Disease variant
Hydroxylation
Intellectual disability
Isopeptide bond
Methylation
Nucleosome core
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2R4R0
P62805

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
chromatin organization	NAS	31790919
nucleosome assembly	IDA	14718166 20498094 21636898 24699735 25615412
nucleosome assembly	IBA
telomere organization	TAS	17675446
negative regulation of megakaryocyte differentiation	IDA	18474616

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin [inference]

protein localization to CENP-A containing chromatin

protein localization to chromosome, centromeric region [inference]

protein localization to CENP-A containing chromatin

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-DNA complex organization [inference]

chromatin organization

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome assembly

protein-DNA complex assembly [inference]

nucleosome assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin [inference]

protein localization to CENP-A containing chromatin

protein localization to chromosome, centromeric region [inference]

protein localization to CENP-A containing chromatin

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin [inference]

protein localization to CENP-A containing chromatin

protein localization to chromosome, centromeric region [inference]

protein localization to CENP-A containing chromatin

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	HDA	19135898
nucleosome	TAS	3035717
nucleosome	IDA	14718166 20498094 21636898 24699735 25615412
nucleosome	IPI	20498094 21812398 24311584 26694698
extracellular region	TAS

GO Hierarchy

cellular component

protein-containing complex

protein-DNA complex [inference]

nucleosome

CENP-A containing nucleosome

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	TAS	3035717
DNA binding	IBA
RNA binding	HDA	22658674 22681889
protein binding	IPI	10220385 14585971 15161933 15933069 16415788 16917504 17540172 18404153 18408754 18474616 18571423 19410544 19494831 19498464 19710015 19862764 20000738 20224553 20498094 20618440 20709061 20739937 20951943 21085121 21478274 21596426 21743476 21888893 21983900 22343720 22368283 22373579 22615379 23071334 23075851 23142979 23377543 23760478 23831576 24183680 24360279 24361270 24525235 24596249 24726341 24981860 25281266 25416956 25556234 25579814 25619998 25651062 25910212 26167883 26496610 26912361 27153538 28514442 30021884 31142837 31759698 32296183 32814053 33857403 33961781 35271311 9540062
structural constituent of chromatin	IDA	14718166

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of chromatin

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

histone H4

Functional Category

F: Nucleotide transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
negative regulation of megakaryocyte differentiation
nucleosome assembly
protein heterodimerization activity
structural constituent of chromatin

Displaying **all 5** entries
InterPro
CENP-T/Histone H4, histone fold
Histone H4, conserved site
Histone H4
Histone-fold
TATA box binding protein associated factor (TAF), histone-like fold domain

Ortholog

Displaying entries **1 - 10** of **538** in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	8294	Xenbase:XB-GENE-6000762
Rattus norvegicus	8329	RGD:1304905
Rattus norvegicus	8330	RGD:1304905
Rattus norvegicus	8332	RGD:1304905
Rattus norvegicus	8336	RGD:1304905
Xenopus tropicalis	8359	Xenbase:XB-GENE-6000762
Xenopus tropicalis	8360	Xenbase:XB-GENE-6000762
Xenopus tropicalis	8361	Xenbase:XB-GENE-6000762
Xenopus tropicalis	8362	Xenbase:XB-GENE-6000762
Xenopus tropicalis	8363	Xenbase:XB-GENE-6000762