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calcium channel, voltage-dependent, L type, alpha 1S subunit

Summary

Gene Symbol

Cacna1s

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12292

PubChem

12292

Alliance of Genome Resources

MGI:88294

Annotation

Keyword

3D-structure
Alternative splicing
Calcium channel
Calmodulin-binding
Cell membrane
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8I4RSM0
Q02789	Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle Dihydropyridine receptor Voltage-gated calcium channel subunit alpha Cav1.1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
skeletal system development	IMP	6501560
extraocular skeletal muscle development	IMP	14618389
calcium ion transport	ISO
calcium ion transport	IDA	12954602
calcium ion transport	IMP	10929205 1663002 9929471

GO Hierarchy

biological process

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cellular developmental process [inference]

cell development [inference]

muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

striated muscle contraction

muscle adaptation [inference]

striated muscle adaptation [inference]

skeletal muscle adaptation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

extraocular skeletal muscle development

cell development [inference]

muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development [inference]

extraocular skeletal muscle development

system development [inference]

skeletal system development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development [inference]

extraocular skeletal muscle development

cellular developmental process [inference]

cell development [inference]

muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

muscle adaptation [inference]

striated muscle adaptation [inference]

skeletal muscle adaptation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

positive regulation of muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
plasma membrane	ISO
voltage-gated calcium channel complex	ISO
voltage-gated calcium channel complex	IBA
sarcoplasmic reticulum	IDA	12954602 15536090 16403451 8943043

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

sarcolemma

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

dendritic spine head

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	ISO
voltage-gated calcium channel activity	IDA	12954602
voltage-gated calcium channel activity	IMP	9929471
calmodulin binding	IEA
high voltage-gated calcium channel activity	ISO