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MIRAGE

AGBL carboxypeptidase 1

Summary

Gene Symbol

AGBL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

123624

PubChem

123624

Alliance of Genome Resources

HGNC:26504

Annotation

Keyword

Carboxypeptidase
Corneal dystrophy
Cytoplasm
Metal-binding
Metalloprotease
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96MI9	ATP/GTP-binding protein-like 1 Protein deglutamylase CCP4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
C-terminal protein deglutamylation	ISS
protein side chain deglutamylation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	IEA
microtubule cytoskeleton	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metallocarboxypeptidase activity	ISS
metallocarboxypeptidase activity	IBA
zinc ion binding	IEA
tubulin binding	ISS
tubulin binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytosolic carboxypeptidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
carboxypeptidase activity
metallocarboxypeptidase activity
proteolysis
zinc ion binding

Displaying **all 4** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Cytosolic carboxypeptidase, N-terminal
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11555	Fuchs' endothelial dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

1

2

3

4

5

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	123624	Xenbase:XB-GENE-5759092
Mus musculus	244071		MOUSE53151
Rattus norvegicus	308724		RATNO16550
Pan troglodytes	467750		PANTR11076
Macaca mulatta	699665		MACMU41573
Monodelphis domestica	100017490		MONDO05604
Equus caballus	100070057		HORSE15866
Ornithorhynchus anatinus	100075393		ORNAN22537
Taeniopygia guttata	100224531		TAEGU01935
Oryctolagus cuniculus	100352303		RABIT16334

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025