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calpastatin

Summary

Gene Symbol

Cast

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12380

PubChem

12380

Alliance of Genome Resources

MGI:1098236

Annotation

Keyword

Acetylation
Alternative splicing
Isopeptide bond
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Thiol protease inhibitor
Ubl conjugation

Proteins

Displaying **all 8** entries
UniProt	Protein Name
Q921U7	Calpain inhibitor
Q3TTN2	Calpain inhibitor
A0A1Y7VJN8	Calpain inhibitor
Q8CE04	Calpain inhibitor
Q8CB83	Calpain inhibitor
Q8CE80	Calpain inhibitor
P51125	Calpain inhibitor
Q8C281	Calpain inhibitor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
egg activation	ISO
negative regulation of peptidase activity	IGI	21849499
protein catabolic process	ISA	11673859
negative regulation of type B pancreatic cell apoptotic process	ISO
negative regulation of type B pancreatic cell apoptotic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cell activation [inference]

egg activation

reproductive process [inference]

egg activation

multicellular organismal process [inference]

cell activation [inference]

egg activation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

regulation of type B pancreatic cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of type B pancreatic cell apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
postsynaptic density	ISO
membrane	ISO
membrane	IDA	11090425

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protease binding	ISO
cysteine-type endopeptidase inhibitor activity
calcium-dependent cysteine-type endopeptidase inhibitor activity	ISO
calcium-dependent cysteine-type endopeptidase inhibitor activity	IBA
calcium-dependent cysteine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

calcium-dependent cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

calcium-dependent cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

calcium-dependent cysteine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

calcium-dependent cysteine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calpastatin isoform a

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
calcium-dependent cysteine-type endopeptidase inhibitor activity
peptidase inhibitor activity

Displaying **all 2** entries
InterPro
Calpastatin
Proteinase inhibitor I27, calpastatin

Ortholog

Displaying entries **11 - 20** of 54 in total

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Species	Gene ID	Orthologous MAtrix
Ornithorhynchus anatinus	100081543	ORNAN12672
Pongo abelii	100174647	PONAB30135
Pongo abelii	100189891	PONAB30135
Taeniopygia guttata	100223192	TAEGU31469
Callithrix jacchus	100391897	CALJA25915
Nomascus leucogenys	100600776	NOMLE25713
Cricetulus griseus	100761152	CRIGR06837
Capra hircus	100861304	CAPHI26940
Pan paniscus	100976348	PANPA32227
Papio anubis	101011082	PAPAN32244