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atypical chemokine receptor 2

Summary

Gene Symbol

ACKR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1238

PubChem

1238

Alliance of Genome Resources

HGNC:1565

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O00590	C-C chemokine receptor D6 Chemokine receptor CCR-10 Chemokine receptor CCR-9 Chemokine-binding protein 2 Chemokine-binding protein D6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
inflammatory response	IEA
immune response	IBA
positive regulation of cytosolic calcium ion concentration	IBA
vesicle-mediated transport	IEA
calcium-mediated signaling	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport

cell motility [inference]

cell migration [inference]

cell chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
early endosome	IEA
cytosol	IDA
actin filament	IDA	23633677
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chemokine receptor activity	IDA	9364936
scavenger receptor activity	IMP	23633677
protein binding	IPI	32296183
C-C chemokine receptor activity	IBA
C-C chemokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

cargo receptor activity [inference]

scavenger receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atypical chemokine receptor 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **41 - 50** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	791973	WB:WBGene00011578
Monodelphis domestica	100026626		MONDO29995
Equus caballus	100067183		HORSE12317
Ornithorhynchus anatinus	100082343		ORNAN05444
Oryctolagus cuniculus	100345678		RABIT12590
Callithrix jacchus	100387549		CALJA13173
Pongo abelii	100433608		PONAB25440
Ailuropoda melanoleuca	100465020		AILME06218
Nomascus leucogenys	100589553		NOMLE28330
Loxodonta africana	100665313		LOXAF14855

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OrthoDB (Group)

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Acknowledgements